Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion.
Reticulation of low density shape memory polymer foam with an in vivo demonstration of vascular occlusion.
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DOI：
10.1016/j.jmbbm.2014.07.037
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发表时间：
2014-12
影响因子：
3.9
通讯作者：
Maitland, Duncan J.
中科院分区：
文献类型：
--
作者：
Rodriguez, Jennifer N.;Miller, Matthew W.;Boyle, Anthony;Horn, John;Yang, Cheng-Kang;Wilson, Thomas S.;Ortega, Jason M.;Small, Ward;Nash, Landon;Skoog, Hunter;Maitland, Duncan J.
最近报道，主要闭孔的低密度形状记忆聚合物（SMP）泡沫是猪模型中的有效动脉瘤填充装置（Rodriguez等人，Journal of Biomedical Materials Research Part A 2013：（http：//dx.doi.org/10.1002/jbm.a.34782））。由于愈合涉及血液凝固和细胞在整个泡沫体积中的迁移，因此更开放的孔结构可以进一步增强愈合反应。本研究试图开发一种非破坏性的网状化过程，这种SMP泡沫破坏孔细胞之间的膜。使用重力驱动的浮动镍钛合金针阵列结合泡沫的振动搅拌和补充化学蚀刻实现非破坏性机械网状化。网状化导致弹性模量降低和渗透性增加，但不妨碍形状记忆行为。网状泡沫能够在体内猪模型中实现快速血管闭塞。
Predominantly closed-cell low density shape memory polymer (SMP) foam was recently reported to be an effective aneurysm filling device in a porcine model (Rodriguez et al., Journal of Biomedical Materials Research Part A 2013: (http://dx.doi.org/10.1002/jbm.a.34782)). Because healing involves blood clotting and cell migration throughout the foam volume, a more open-cell structure may further enhance the healing response. This research sought to develop a non-destructive reticulation process for this SMP foam to disrupt the membranes between pore cells. Non-destructive mechanical reticulation was achieved using a gravity-driven floating nitinol pin array coupled with vibratory agitation of the foam and supplemental chemical etching. Reticulation resulted in a reduced elastic modulus and increased permeability, but did not impede shape memory behavior. Reticulated foams were capable of achieving rapid vascular occlusion in an in vivo porcine model.
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影响因子：
2.6
作者：
Kipshidze, N;Sadzaglishvili, K;Leon, MB
通讯作者：
Leon, MB
DOI：
10.2118/4706-pa
发表时间：
1974-01-01
期刊：
SOCIETY OF PETROLEUM ENGINEERS JOURNAL
影响因子：
--
作者：
GEERTSMA, J
通讯作者：
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影响因子：
--
作者：
Singhal, Pooja;Rodriguez, Jennifer N.;Small, Ward;Eagleston, Scott;de Water, Judy Van;Maitland, Duncan J.;Wilson, Thomas S.
通讯作者：
Wilson, Thomas S.
DOI：
10.3174/ajnr.a2419
发表时间：
2011-01
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Cebral JR;Mut F;Weir J;Putman C
通讯作者：
Putman C
影响因子：
2.5
作者：
Singhal, Pooja;Boyle, Anthony;Brooks, Marilyn L.;Infanger, Stephen;Letts, Steve;Small, Ward;Maitland, Duncan J.;Wilson, Thomas S.
通讯作者：
Wilson, Thomas S.