A comparison of health-related quality of life in autonomic disorders: postural tachycardia syndrome versus vasovagal syncope.
A comparison of health-related quality of life in autonomic disorders: postural tachycardia syndrome versus vasovagal syncope.
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DOI：
10.1007/s10286-021-00781-x
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
Raj SR
中科院分区：
文献类型：
--
作者：
Hall J;Bourne KM;Sheldon RS;Vernino S;Raj V;Ng J;Okamoto LE;Arnold AC;Bryarly M;Phillips L;Paranjape SY;Raj SR
体位性心动过速综合征(POTS)和血管迷走性晕厥(VVS)是两种立位耐力障碍，常被误诊为另一种。在每种情况下，与健康人群相比，患者体验到的健康相关生活质量(HRQOL)都有所降低。这项研究是为了验证POTS中HRQL更差的假设。POTS患者是从自主障碍国际年度患者和照顾者会议上招募的。VVS患者的数据来自参加第二次预防晕厥试验的人。参与者≥18岁(177个POTS和72个VV)完成了兰德36项健康调查，这是一项与健康相关的通用和连贯的生活质量调查。与VVS患者相比，POTS患者在以下几个方面降低了生存质量：身体功能(42.5vs.76.5vs.76.52.9p<；0.001)，身体健康(11.4vs.33.0vs.33.0±5.0p<；0.001)，精力和疲劳(27.2士1.3vs.50.7±2.6p<；0.001)，社交功能(45.2vs.71.2vs.71.2±2.9p<；0.001)；0.001)、疼痛(48.8±1.9vs.67.7±2.9p<；0.001)和一般健康(31.2vs.60.52.6p<；0.001)领域。由于情绪健康(p=0.052)和情绪幸福感(p=0.271)领域的角色限制，得分没有显著差异。POTS人群的身体健康和一般健康综合得分较低，而心理健康综合得分没有差异。在这些患者群体之间存在着HRQL的差异。POTS患者在生理和一般健康领域的得分低于VVS患者，但情感健康领域没有显著差异。针对这些患者的身体功能可能有助于提高生活质量。
Postural tachycardia syndrome (POTS) and vasovagal syncope (VVS) are two disorders of orthostatic intolerance which are often misdiagnosed as the other. In each case, patients experience a reduced health-related quality of life (HRQoL) compared to healthy populations. This study was conducted to test the hypothesis that HRQoL is worse in POTS. POTS patients were recruited from the Dysautonomia International Annual Patient and Caregiver Conference. VVS patient data came from those enrolled in the Second Prevention of Syncope Trial. Participants ≥18 years (177 POTS and 72 VVS) completed the RAND 36-Item Health Survey, a generic and coherent health-related quality of life survey. POTS patients reported reduced HRQoL compared to VVS patients in physical functioning (42.5±1.7 vs. 76.5±2.9, p<0.001), role limitations due to physical health (11.4±1.9 vs. 33.0±5.0, p<0.001), energy and fatigue (27.2±1.3 vs. 50.7±2.6, p<0.001), social functioning (45.2±1.8 vs 71.2±2.9, p<0.001), pain (48.8±1.9 vs. 67.7±2.9, p<0.001), and general health (31.2±1.5 vs. 60.5±2.6, p<0.001) domains. Scores did not differ significantly in the role limitations due to emotional health (p=0.052) and emotional well-being (p=0.271) domains. Physical and general health composite scores were lower in the POTS population, while mental health composite scores were not different. Differences in HRQoL exist between these patient populations. POTS patients report lower scores in physical and general health domains than VVS patients, but emotional health domains do not differ significantly. Targeting physical functioning in these patients may help improve quality of life.
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影响因子：
11.1
作者：
Shaw, B. H.;Stiles, L. E.;Raj, S. R.
通讯作者：
Raj, S. R.
影响因子：
3.6
作者：
McCarthy, Kevin;Ward, Mark;Kenny, Rose Anne
通讯作者：
Kenny, Rose Anne
影响因子：
8.9
作者：
Benrud-Larson, LM;Dewar, MS;Low, PA
通讯作者：
Low, PA
DOI：
10.1136/jnnp.2008.144360
发表时间：
2009-03
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Raj V;Haman KL;Raj SR;Byrne D;Blakely RD;Biaggioni I;Robertson D;Shelton RC
通讯作者：
Shelton RC
影响因子：
2.4
作者：
Nwazue, Victor C.;Raj, Satish R.
通讯作者：
Raj, Satish R.