Changes in the Gene Expression of C-myc and CD38 in HL-60 Cells during Differentiation Induced by Nicotinic Acid-Related Compounds
Changes in the Gene Expression of C-myc and CD38 in HL-60 Cells during Differentiation Induced by Nicotinic Acid-Related Compounds
复制标题
烟酸相关化合物诱导HL-60细胞分化过程中C-myc和CD38基因表达的变化
DOI：
--
复制
发表时间：
2008
期刊：
影响因子：
--
通讯作者：
H. Taguchi
中科院分区：
文献类型：
--
作者：
Chieri Ida;S. Ogata;K. Okumura;H. Taguchi
在HL-60细胞向粒细胞分化的过程中，由于三种烟酸相关化合物，c-myc和CD 38基因表达水平的变化进行了检查。异烟酸和全反式维甲酸（ATRA）可增加CD 38的表达。烟酰胺和烟酰胺N-氧化物显著降低c-myc表达，但异烟酸没有影响，表明这些化合物通过不同途径将HL-60分化为粒细胞。这些结果应提供有用的信息，细胞分化的机制。
Changes in gene expression levels of c-myc and CD38 were examined during the differentiation of HL-60 cells to granulocytes due to three nicotinic acid-related compounds. CD38 expression was increased by isonicotinic acid and all-trans-retinoic acid (ATRA). Nicotinamide and nicotinamide N-oxide drastically decreased c-myc expression, but isonicotinic acid had no effect, suggesting that these compounds differentiate HL-60 to granulocytes through different pathways. These results should provide useful information as to the mechanisms of cell differentiation.
HL-60 细胞系中 c-myc 表达的调节。
DOI：
10.1016/s0006-291x(84)80273-9
发表时间：
1984
影响因子：
3.1
作者：
Grosso,LE;Pitot,HC
通讯作者：
Pitot,HC