Correlates of protection against SARS-CoV-2 in rhesus macaques.
Correlates of protection against SARS-CoV-2 in rhesus macaques.
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恒河猴抗SARS-CoV-2的相关性研究
DOI：
10.1038/s41586-020-03041-6
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发表时间：
2021-03
期刊：
影响因子：
64.8
通讯作者：
Barouch DH
中科院分区：
文献类型：
--
作者：
McMahan K;Yu J;Mercado NB;Loos C;Tostanoski LH;Chandrashekar A;Liu J;Peter L;Atyeo C;Zhu A;Bondzie EA;Dagotto G;Gebre MS;Jacob-Dolan C;Li Z;Nampanya F;Patel S;Pessaint L;Van Ry A;Blade K;Yalley-Ogunro J;Cabus M;Brown R;Cook A;Teow E;Andersen H;Lewis MG;Lauffenburger DA;Alter G;Barouch DH
最近的研究报道了恒河猴的天然免疫和疫苗诱导的免疫对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）攻击的保护效果。然而，体液免疫和细胞免疫对SARS-CoV-2感染的重要性仍有待确定。在这里，我们表明，过继转移的纯化IgG从恢复期猕猴保护幼稚受体恒河猴对SARS-CoV-2的挑战，在剂量依赖性的方式。在恢复期动物中，CD 8 + T细胞的耗竭部分消除了天然免疫对SARS-CoV-2再攻击的保护效力，表明细胞免疫在抗体滴度减弱或亚保护的情况下的重要性。这些数据表明，相对较低的抗体滴度足以保护恒河猴免受SARS-CoV-2的侵害，如果抗体应答不理想，细胞免疫应答也可能有助于保护。我们还表明，更高的抗体滴度是治疗SARS-CoV-2感染猕猴所必需的。这些发现对SARS-CoV-2疫苗和免疫疗法的开发具有重要意义。
Recent studies have reported protective efficacy of both natural immunity and vaccine-induced immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) challenge in rhesus macaques. However, the importance of humoral and cellular immunity for protection against SARS-CoV-2 infection remains to be determined. Here we show that adoptive transfer of purified IgG from convalescent macaques protects naïve recipient rhesus macaques against SARS-CoV-2 challenge in a dose dependent fashion. Depletion of CD8+ T cells in convalescent animals partially abrogated the protective efficacy of natural immunity against SARS-CoV-2 re-challenge, suggesting the importance of cellular immunity in the context of waning or subprotective antibody titers. These data demonstrate that relatively low antibody titers are sufficient for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may also contribute to protection if antibody responses are suboptimal. We also show that higher antibody titers are required for therapy of SARS-CoV-2 infection in macaques. These findings have important implications for the development of SARS-CoV-2 vaccines and immune-based therapeutics.
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影响因子：
64.8
作者：
van Doremalen N;Lambe T;Spencer A;Belij-Rammerstorfer S;Purushotham JN;Port JR;Avanzato VA;Bushmaker T;Flaxman A;Ulaszewska M;Feldmann F;Allen ER;Sharpe H;Schulz J;Holbrook M;Okumura A;Meade-White K;Pérez-Pérez L;Edwards NJ;Wright D;Bissett C;Gilbride C;Williamson BN;Rosenke R;Long D;Ishwarbhai A;Kailath R;Rose L;Morris S;Powers C;Lovaglio J;Hanley PW;Scott D;Saturday G;de Wit E;Gilbert SC;Munster VJ
通讯作者：
Munster VJ
影响因子：
64.8
作者：
Zost SJ;Gilchuk P;Case JB;Binshtein E;Chen RE;Nkolola JP;Schäfer A;Reidy JX;Trivette A;Nargi RS;Sutton RE;Suryadevara N;Martinez DR;Williamson LE;Chen EC;Jones T;Day S;Myers L;Hassan AO;Kafai NM;Winkler ES;Fox JM;Shrihari S;Mueller BK;Meiler J;Chandrashekar A;Mercado NB;Steinhardt JJ;Ren K;Loo YM;Kallewaard NL;McCune BT;Keeler SP;Holtzman MJ;Barouch DH;Gralinski LE;Baric RS;Thackray LB;Diamond MS;Carnahan RH;Crowe JE Jr
通讯作者：
Crowe JE Jr
影响因子：
64.5
作者：
Chung AW;Kumar MP;Arnold KB;Yu WH;Schoen MK;Dunphy LJ;Suscovich TJ;Frahm N;Linde C;Mahan AE;Hoffner M;Streeck H;Ackerman ME;McElrath MJ;Schuitemaker H;Pau MG;Baden LR;Kim JH;Michael NL;Barouch DH;Lauffenburger DA;Alter G
通讯作者：
Alter G
影响因子：
56.9
作者：
Yu, Jingyou;Tostanoski, Lisa H.;Barouch, Dan H.
通讯作者：
Barouch, Dan H.
影响因子：
56.9
作者：
Chandrashekar, Abishek;Liu, Jinyan;Barouch, Dan H.
通讯作者：
Barouch, Dan H.