Innate immune system and tissue regeneration in planarians: an area ripe for exploration.
Innate immune system and tissue regeneration in planarians: an area ripe for exploration.
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DOI：
10.1016/j.smim.2014.06.005
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发表时间：
2014-08
影响因子：
7.8
通讯作者：
Oviedo NJ
中科院分区：
文献类型：
--
作者：
Peiris TH;Hoyer KK;Oviedo NJ
免疫系统被认为是组织再生的重要调节剂。然而，驱动损伤诱导的免疫应答和组织修复的机制仍然知之甚少。200多年来，真涡虫一直是研究组织再生的经典模型，但真涡虫的免疫系统及其在修复中的潜在作用在很大程度上是未知的。我们通过比较基因组分析和数据挖掘发现，涡虫含有许多先天免疫系统的潜在同源物，这些同源物在成体组织的损伤和修复过程中被激活。这些发现支持了这样一种观点，即成体组织修复和免疫系统之间的关系是基底两侧动脉的一个古老特征。在再生过程中对Planarian免疫系统的进一步分析可能会增加我们对先天免疫系统和炎症反应如何与再生信号相互作用以在成年生物体的背景下诱导无瘢痕组织修复的理解。
The immune system has been implicated as an important modulator of tissue regeneration. However, the mechanisms driving injury-induced immune response and tissue repair remain poorly understood. For over 200 years, planarians have been a classical model for studies on tissue regeneration, but the planarian immune system and its potential role in repair is largely unknown. We found through comparative genomic analysis and data mining that planarians contain many potential homologs of the innate immune system that are activated during injury and repair of adult tissues. These findings support the notion that the relationship between adult tissue repair and the immune system is an ancient feature of basal Bilateria. Further analysis of the planarian immune system during regeneration could potentially add to our understanding of how the innate immune system and inflammatory responses interplay with regenerative signals to induce scar-less tissue repair in the context of the adult organism.
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DOI：
10.1073/pnas.1305923110
发表时间：
2013-06-25
影响因子：
11.1
作者：
Barr, Jeremy J.;Auro, Rita;Rohwer, Forest
通讯作者：
Rohwer, Forest
影响因子：
10.7
作者：
Alcaide, Miguel;Edwards, Scott V.
通讯作者：
Edwards, Scott V.
影响因子：
2.4
作者：
Chalmers IW;Hoffmann KF
通讯作者：
Hoffmann KF
影响因子：
--
作者：
Elliott, Sarah A.;Alvarado, Alejandro Sanchez
通讯作者：
Alvarado, Alejandro Sanchez
影响因子：
6.7
作者：
Collins JJ 3rd;Newmark PA
通讯作者：
Newmark PA