Circulating prolactin associates with diabetes and impaired glucose regulation: a population-based study.
Circulating prolactin associates with diabetes and impaired glucose regulation: a population-based study.
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DOI：
10.2337/dc12-1893
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发表时间：
2013-07
期刊：
影响因子：
16.2
通讯作者：
Ning G
中科院分区：
文献类型：
--
作者：
Wang T;Lu J;Xu Y;Li M;Sun J;Zhang J;Xu B;Xu M;Chen Y;Bi Y;Wang W;Ning G
催乳素是妊娠期间β细胞适应的主要刺激物，并保护产后妇女免受妊娠期糖尿病的侵害。大多数催乳素对葡萄糖代谢作用的研究都是在人类和动物妊娠期间进行的。然而，在流行病学研究中，关于循环催乳素和妊娠外葡萄糖代谢之间的关联知之甚少。我们的目的是确定是否循环催乳素浓度的变化与糖尿病和糖调节受损（IGR）的横断面研究。我们在中国上海招募了2,377名40岁及以上无高泌乳素血症的受试者（1,034名男性和1,343名绝经后女性）。糖尿病和IGR通过口服葡萄糖耐量试验确定。采用多项logit分析评价催乳素与糖尿病和IGR的关系。从正常血糖调节到IGR再到糖尿病，催乳素水平下降。调整潜在混杂因素后的多项logit分析显示，高循环催乳素与糖尿病和IGR的低患病率相关。最高与最低四分位数催乳素的IGR和糖尿病的校正比值比（95%CI）在男性中分别为0.54（95%CI 0.33-0.89）和0.38（0.24-0.59），在女性中分别为0.54（0.36-0.81）和0.47（0.32-0.70）。目前的研究表明，高循环催乳素与糖尿病和IGR的发病率较低有关。需要进一步的研究来证实这种关联。
Prolactin is a major stimulus for the β-cell adaptation during gestation and guards postpartum women against gestational diabetes. Most studies of the role of prolactin on glucose metabolism have been conducted in humans and animals during pregnancy. However, little is known concerning the association between circulating prolactin and glucose metabolism outside pregnancy in epidemiological studies. We aimed to determine whether the variation of circulating prolactin concentration associates with diabetes and impaired glucose regulation (IGR) in a cross-sectional study. We recruited 2,377 participants (1,034 men and 1,343 postmenopausal women) without hyperprolactinemia, aged 40 years and older, in Shanghai, China. Diabetes and IGR were determined by an oral glucose tolerance test. Multinomial logit analyses were performed to evaluate the relationship of prolactin with diabetes and IGR. Prolactin levels decreased from normal glucose regulation to IGR to diabetes. Multinomial logit analyses, adjusted for potential confounding factors, showed that high circulating prolactin was associated with lower prevalence of diabetes and IGR. The adjusted odds ratios (95% CI) for IGR and diabetes for the highest compared with the lowest quartile of prolactin were 0.54 (95% CI 0.33–0.89) and 0.38 (0.24–0.59) in men and 0.54 (0.36–0.81) and 0.47 (0.32–0.70) in women. High circulating prolactin associates with lower prevalence of diabetes and IGR in the current study. Further studies are warranted to confirm this association.
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DOI：
10.1016/j.bbrc.2005.04.026
发表时间：
2005-06-17
影响因子：
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