Fit4Life: a weight loss intervention for children who have survived childhood leukemia.
Fit4Life: a weight loss intervention for children who have survived childhood leukemia.
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DOI：
10.1002/pbc.24937
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发表时间：
2014-05
影响因子：
3.2
通讯作者：
Patrick, Kevin
中科院分区：
文献类型：
--
作者：
Huang, Jeannie S.;Dillon, Lindsay;Terrones, Laura;Schubert, Lynn;Roberts, William;Finklestein, Jerry;Swartz, Maria C.;Norman, Gregory J.;Patrick, Kevin
急性淋巴细胞白血病（ALL）幸存儿童超重和肥胖的风险高于一般人群。对于癌症幸存者来说，是否需要一种通用的或量身定制的体重管理方法还有待检验。招募了38名8-18岁的BMI≥85%的ALL幸存者参加随机临床试验，评价为儿童ALL幸存者量身定制的体重管理干预（Fit 4Life）。Fit 4Life的接受者接受了为期4个月的网络，电话和短信交付的癌症生存量身定制的治疗。对照组收到了通过电话和邮件发送的一般通知。在基线和4个月时进行评估。根据分配的治疗条件随时间推移分析结局数据。大部分（80%（70%，100%）[中位数（IQR）]）的指定课程由Fit 4Life参与者接受，而对照组中为50%（40%，65%）。与对照组相比，14岁以上的Fit 4Life接受者体重增加较少（p=0.05），中度至剧烈体力活动增加（p<0.01），而所有Fit 4Life接受者报告随着时间的推移负面情绪减少（p<0.05）。我们证明了可接受的可行性，为超重和肥胖儿童生存的ALL利用多模式技术的方法定制的治疗。与接受普通减肥药的青少年相比，Fit 4Life干预显示出体重、体重相关行为和心理结果的改善。这项试点试验的数据可用于设计一项更大规模的试验，以确定所有年龄段的青少年是否也可以从癌症幸存者定制的治疗中获益，以及短期结果是否转化为儿童ALL幸存者的长期结果改善。
Children surviving acute lymphoblastic leukemia (ALL) are at increased risk for overweight and obesity over that of the general population. Whether a generic or tailored approach to weight management is needed for cancer survivors has yet to be tested. Thirty-eight youth 8–18 years with BMI≥85% who had survived ALL were recruited for a randomized clinical trial evaluating a weight management intervention (WMI) tailored for childhood ALL survivors (Fit4Life). Fit4Life recipients received a 4-month web, phone, and text message-delivered WMI tailored for cancer survivorship. Controls received a general WMI delivered via phone and mail. Assessments were performed at baseline and 4 months. Outcome data were analyzed according to assigned treatment condition over time. Most (80% (70%,100%) [median (IQR)]) of the assigned curriculum was received by Fit4Life participants as compared to 50% (40%,65%) among controls. Fit4Life recipients ≥14 years demonstrated less weight gain (p=0.05) and increased moderate-to-vigorous physical activity (p<0.01) while all Fit4Life recipients reported reduced negative mood (p<0.05) over time as compared to control counterparts. We demonstrated acceptable feasibility of a WMI tailored for overweight and obese children surviving ALL utilizing a multimodal technology approach. Improved weight, weight-related behavior, and psychological outcomes were demonstrated among Fit4Life intervention as compared to youth receiving a generic WMI. Data from this pilot trial may be used to design a larger trial to determine whether youth of all ages also can derive a benefit from a cancer-survivor tailored WMI and whether short-term outcomes translate into improved long-term outcomes for childhood ALL survivors.
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影响因子：
--
作者：
Mayer, EIE;Reuter, M;Ranke, MB
通讯作者：
Ranke, MB
DOI：
10.1016/s0002-8223(98)00097-2
发表时间：
1998-04-01
影响因子：
--
作者：
Champagne, CM;Baker, NB;Bray, GA
通讯作者：
Bray, GA
影响因子：
8
作者：
Barlow, SE;Dietz, WH
通讯作者：
Dietz, WH
影响因子：
39.2
作者：
Digenio, Andres G.;Mancuso, James P.;Dvorak, Roman V.
通讯作者：
Dvorak, Roman V.
影响因子：
6.2
作者：
Meacham, LR;Gurney, JG;Oeffinger, KC
通讯作者：
Oeffinger, KC