Comparative analysis examining patterns of genomic differentiation across multiple episodes of population divergence in birds.
Comparative analysis examining patterns of genomic differentiation across multiple episodes of population divergence in birds.
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DOI：
10.1002/evl3.46
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发表时间：
2018-04
影响因子：
5
通讯作者：
Liedvogel M
中科院分区：
文献类型：
--
作者：
Delmore KE;Lugo Ramos JS;Van Doren BM;Lundberg M;Bensch S;Irwin DE;Liedvogel M
基因组分化的异质性模式通常在密切相关的种群之间被记录在案，人们对识别促成它们形成的因素非常感兴趣。这些因子可能包括在特定基因组区域促进连锁选择(影响连锁中性位点的正选择或净化选择)等过程的基因组特征(例如，低重组区域)。对群体间可重复的分化模式的检查可以提供对这些因素作用的洞察。鸟类非常适合这项工作，因为基因组结构在这个群体中是保守的。因此，我们使用一个共同的管道重新估计了跨越广泛分类范围的八对姊妹鸟之间的相对(FST)和绝对(DXY)差异。在不同配对中，基于窗口的分化估计之间存在着适度但显著的相关性(FST和DXY分别解释了高达3%和26%的变异)，支持保守基因组特征的过程在产生异质性分化模式中的作用；群体分化的每一幕特有的过程可能解释了剩余的变异。确定几个基因组变量(例如，基因密度)作为FST和DXY重复性的重要预测因子的线性模型加强了基因组特征所起的作用。FST重复性在沿着物种形成连续体更远的配对中更高(即更具生殖隔离)，为进一步了解基因组分化如何随着种群分化而变化提供了进一步的洞察；物种形成的早期阶段可能以正向选择为主，这种选择在配对之间不同，但随着物种形成的进行，它与根据共同基因组特征发挥作用的过程相结合。
Heterogeneous patterns of genomic differentiation are commonly documented between closely related populations and there is considerable interest in identifying factors that contribute to their formation. These factors could include genomic features (e.g., areas of low recombination) that promote processes like linked selection (positive or purifying selection that affects linked neutral sites) at specific genomic regions. Examinations of repeatable patterns of differentiation across population pairs can provide insight into the role of these factors. Birds are well suited for this work, as genome structure is conserved across this group. Accordingly, we reestimated relative (FST) and absolute (dXY) differentiation between eight sister pairs of birds that span a broad taxonomic range using a common pipeline. Across pairs, there were modest but significant correlations in window‐based estimates of differentiation (up to 3% of variation explained for FST and 26% for dXY), supporting a role for processes at conserved genomic features in generating heterogeneous patterns of differentiation; processes specific to each episode of population divergence likely explain the remaining variation. The role genomic features play was reinforced by linear models identifying several genomic variables (e.g., gene densities) as significant predictors of FST and dXY repeatability. FST repeatability was higher among pairs that were further along the speciation continuum (i.e., more reproductively isolated) providing further insight into how genomic differentiation changes with population divergence; early stages of speciation may be dominated by positive selection that is different between pairs but becomes integrated with processes acting according to shared genomic features as speciation proceeds.
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影响因子：
7
作者：
Han F;Lamichhaney S;Grant BR;Grant PR;Andersson L;Webster MT
通讯作者：
Webster MT
影响因子：
1.7
作者：
Griffin, D. K.;Robertson, L. B. W.;Skinner, B. M.
通讯作者：
Skinner, B. M.
影响因子：
10.7
作者：
Charlesworth, B
通讯作者：
Charlesworth, B
DOI：
10.1098/rspb.2016.2756
发表时间：
2017-02-22
影响因子：
4.7
作者：
Dutoit, Ludovic;Vijay, Nagarjun;Ellegren, Hans
通讯作者：
Ellegren, Hans
影响因子：
16.6
作者：
Clarkson, Chris S.;Weetman, David;Essandoh, John;Yawson, Alexander E.;Maslen, Gareth;Manske, Magnus;Field, Stuart G.;Webster, Mark;Antao, Tiago;MacInnis, Bronwyn;Kwiatkowski, Dominic;Donnelly, Martin J.
通讯作者：
Donnelly, Martin J.