Adaptive introgression between Anopheles sibling species eliminates a major genomic island but not reproductive isolation.
Adaptive introgression between Anopheles sibling species eliminates a major genomic island but not reproductive isolation.
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DOI：
10.1038/ncomms5248
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发表时间：
2014-06-25
影响因子：
16.6
通讯作者：
Donnelly, Martin J.
中科院分区：
文献类型：
--
作者：
Clarkson, Chris S.;Weetman, David;Essandoh, John;Yawson, Alexander E.;Maslen, Gareth;Manske, Magnus;Field, Stuart G.;Webster, Mark;Antao, Tiago;MacInnis, Bronwyn;Kwiatkowski, Dominic;Donnelly, Martin J.
适应性基因渗入可以提供新的遗传变异来促进快速的进化反应，尽管它可能会被受体基因组背景的潜在有害破坏所抵消。我们研究了最近强选择的杀虫剂抗性突变 (Vgsc-1014F) 基因渗入的程度和影响，该突变位于分隔冈比亚按蚊物种对的两个异常大的基因组分歧岛之一内。在这里，我们表明 Vgsc 突变的转移会导致物种之间整个基因组岛区域（约占基因组的 1.5%）的同质化。尽管存在这种巨大的破坏，基因渗入显然具有适应性，Vgsc-1014F 的频率急剧上升，并且对随后的物种间生殖隔离没有明显影响。我们的结果表明（1）基因组对大规模基因渗入的恢复能力如何能够对人为选择做出快速适应性反应；（2）即使基因组分歧岛的极端突出也可能成为物种形成重要性的不可靠指标。 冈比亚按蚊的一对蚊子之间存在高度差异的基因组岛。克拉克森等人在这里。研究表明，由于杀虫剂抗性突变的适应性渗入而导致最大岛屿之一的丧失，对生殖隔离没有影响。
Adaptive introgression can provide novel genetic variation to fuel rapid evolutionary responses, though it may be counterbalanced by potential for detrimental disruption of the recipient genomic background. We examine the extent and impact of recent introgression of a strongly selected insecticide-resistance mutation (Vgsc-1014F) located within one of two exceptionally large genomic islands of divergence separating the Anopheles gambiae species pair. Here we show that transfer of the Vgsc mutation results in homogenization of the entire genomic island region (~1.5% of the genome) between species. Despite this massive disruption, introgression is clearly adaptive with a dramatic rise in frequency of Vgsc-1014F and no discernable impact on subsequent reproductive isolation between species. Our results show (1) how resilience of genomes to massive introgression can permit rapid adaptive response to anthropogenic selection and (2) that even extreme prominence of genomic islands of divergence can be an unreliable indicator of importance in speciation. Highly divergent genomic islands segregate between a species pair of the mosquito, Anopheles gambiae. Here Clarkson et al. show that loss of one of the largest islands, driven by adaptive introgression of an insecticide-resistance mutation, had no impact on reproductive isolation.
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