Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST).
Folic acid supplementation before and during pregnancy in the Newborn Epigenetics STudy (NEST).
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DOI：
10.1186/1471-2458-11-46
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发表时间：
2011-01-21
影响因子：
4.5
通讯作者：
Murphy SK
中科院分区：
文献类型：
--
作者：
Hoyo C;Murtha AP;Schildkraut JM;Forman MR;Calingaert B;Demark-Wahnefried W;Kurtzberg J;Jirtle RL;Murphy SK
在强化过程中添加到食品中的叶酸（FA）的生物利用度为70-85%，而食品中天然存在的叶酸为50%。因此，如果在怀孕期间也服用FA补充剂，母亲和胎儿都可能暴露于FA，超过医学研究所建议的成年孕妇每天1，000微克（μg/d）的可耐受上限（TUL）。主要目的是估计在怀孕前和怀孕期间服用超过TUL的叶酸（FA）剂量的妇女比例，并确定高FA使用的相关性。在2005-2008年期间，通过对北卡罗来纳州达勒姆县两个产科护理机构登记的539名孕妇进行访谈，获得了关于膳食补充剂的孕前和妊娠相关数据。在怀孕前，51%的女性报告补充了FA，66%的女性报告在怀孕期间补充了FA。在怀孕前，11.9%（95% CI = 9.2%-14.6%）的女性报告补充了超过TUL 1，000 μg/天的FA剂量，并且类似比例的女性报告了产前摄入量。在怀孕前，与非洲裔美国女性相比，白人女性更有可能服用高于TUL的FA剂量（OR = 2.99; 95% = 1.28-7.00），而患有慢性疾病的女性不太可能服用高于TUL的FA剂量（OR = 0.48; 95%CI = 0.21-0.97）。与非裔美国女性相比，白人女性也更可能报告妊娠期间摄入超过TUL剂量的FA（OR = 5.09; 95%CI = 2.07-12.49）。51%的女性在怀孕前和怀孕期间分别报告了一些FA摄入量，超过十分之一的女性服用了超过TUL剂量的FA补充剂。高加索妇女更有可能报告高FA摄入量。目前正在进行一项研究，以确定这些高剂量可能产生的遗传和非遗传毒性效应。
Folic acid (FA) added to foods during fortification is 70-85% bioavailable compared to 50% of folate occurring naturally in foods. Thus, if FA supplements also are taken during pregnancy, both mother and fetus can be exposed to FA exceeding the Institute of Medicine's recommended tolerable upper limit (TUL) of 1,000 micrograms per day (μg/d) for adult pregnant women. The primary objective is to estimate the proportion of women taking folic acid (FA) doses exceeding the TUL before and during pregnancy, and to identify correlates of high FA use. During 2005-2008, pre-pregnancy and pregnancy-related data on dietary supplementation were obtained by interviewing 539 pregnant women enrolled at two obstetrics-care facilities in Durham County, North Carolina. Before pregnancy, 51% of women reported FA supplementation and 66% reported this supplementation during pregnancy. Before pregnancy, 11.9% (95% CI = 9.2%-14.6%) of women reported supplementation with FA doses above the TUL of 1,000 μg/day, and a similar proportion reported this intake prenatally. Before pregnancy, Caucasian women were more likely to take FA doses above the TUL (OR = 2.99; 95% = 1.28-7.00), compared to African American women, while women with chronic conditions were less likely to take FA doses above the TUL (OR = 0.48; 95%CI = 0.21-0.97). Compared to African American women, Caucasian women were also more likely to report FA intake in doses exceeding the TUL during pregnancy (OR = 5.09; 95%CI = 2.07-12.49). Fifty-one percent of women reported some FA intake before and 66% during pregnancy, respectively, and more than one in ten women took FA supplements in doses that exceeded the TUL. Caucasian women were more likely to report high FA intake. A study is ongoing to identify possible genetic and non-genotoxic effects of these high doses.
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影响因子：
12.7
作者：
Bentley, Tanya G. K.;Willett, Walter C.;Kuntz, Karen M.
通讯作者：
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影响因子：
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作者：
CZEIZEL, AE;DUDAS, I
通讯作者：
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DOI：
10.1016/s1701-2163(16)32227-7
发表时间：
2006-08-01
影响因子：
1.8
作者：
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作者：
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通讯作者：
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影响因子：
9.8
作者：
DeBaun, MR;Niemitz, EL;Feinberg, AP
通讯作者：
Feinberg, AP