Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization.
Associations between free fatty acids, cumulus oocyte complex morphology and ovarian function during in vitro fertilization.
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DOI：
10.1016/j.fertnstert.2011.01.154
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发表时间：
2011-05
影响因子：
6.7
通讯作者：
Moley, Kelle H.
中科院分区：
文献类型：
--
作者：
Jungheim, Emily S.;Macones, George A.;Odem, Randall R.;Patterson, Bruce W.;Lanzendorf, Susan E.;Ratts, Valerie S.;Moley, Kelle H.
为了确定卵泡游离脂肪酸（FFA）水平是否与卵丘细胞复合体形态相关，前瞻性队列研究大学体外受精（IVF）实践了102名接受体外受精的妇女血清和卵巢卵泡液中游离脂肪酸的测量总和特异性卵泡和血清游离脂肪酸水平，卵泡和血清游离脂肪酸之间的相关性，以及卵泡FFA水平与卵母细胞质量标志物（包括卵母细胞积云复合体（COC）形态）之间的关系。主要的卵泡液和血清FFA为油酸、棕榈酸、亚油酸和硬脂酸。卵泡和血清FFA浓度之间的相关性较弱（特异性FFA的r=0.252, 0.288, 0.236, 0.309，总FFA的r=0.212）。接受者操作者特征曲线确定总卵泡FFAs≥0.232µmol/ml，以较低的COCs百分比与较高的COCs百分比区分具有良好形态的女性。卵泡FFAs升高的女性（n=31）比其他女性（n=71）更容易发生形态不良的COCs （OR 3.3, 95% CI: 1.2-9.2）。在调整了潜在的混杂因素，包括年龄、BMI、子宫内膜异位症和促性腺激素的使用量后，这种关系仍然存在（β=1.2; OR 3.4, 95% CI: 1.1-10.4）。卵泡FFA水平升高与COC形态不良有关。需要进一步的工作来确定什么因素影响卵泡FFA水平，以及这些因素是否影响生育能力。
To determine if follicular free fatty acid (FFA) levels are associated with cumulus oocyte complex morphology Prospective cohort study University in vitro fertilization (IVF) practice 102 women undergoing IVF Measurement of FFAs in serum and ovarian follicular fluid Total and specific follicular and serum FFA levels, correlations between follicular and serum FFAs, and associations between follicular FFA levels and markers of oocyte quality including cumulus oocyte complex (COC) morphology Predominant follicular fluid and serum FFAs were oleic, palmitic, linoleic and stearic acids. Correlations between follicular and serum FFA concentrations were weak (r=0.252, 0.288, 0.236, 0.309 respectively for specific FFAs; r=0.212 for total FFAs). A receiver operator characteristic curve determined total follicular FFAs ≥ 0.232 µmol/ml distinguished women with lower versus higher percentage COCs with favorable morphology. Women with elevated follicular FFAs (n=31) were more likely to have COCs with poor morphology than others (n=71) (OR 3.3, 95% CI:1.2–9.2). This relationship held after adjusting for potential confounders including age, BMI, endometriosis and amount of gonadotropin administered (β=1.2; OR 3.4, 95% CI:1.1–10.4). Elevated follicular FFA levels are associated with poor COC morphology. Further work is needed to determine what factors influence follicular FFA levels and if these factors impact fertility.
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影响因子：
9.8
作者：
Jungheim ES;Moley KH
通讯作者：
Moley KH
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2.5
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Downs, Stephen M.;Mosey, Jessica L.;Klinger, Jonathan
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3.2
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HOLTE, J;BERGH, T;LITHELL, H
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Whitcomb, R
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2.2
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de Kruif, A