Circadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock.

Circadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock.
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DOI:
10.1038/s41477-018-0224-8
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发表时间:
2018-09
期刊:
影响因子:
18
通讯作者:
Webb AAR
Webb AAR
中科院分区:
生物学1区
文献类型:
--
作者:
Martí Ruiz MC;Hubbard KE;Gardner MJ;Jung HJ;Aubry S;Hotta CT;Mohd-Noh NI;Robertson FC;Hearn TJ;Tsai YC;Dodd AN;Hannah M;Carré IA;Davies JM;Braam J;Webb AAR

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在过去的十年中,对昼夜节律振荡器的看法已经从转录反馈扩展到包括转录后、翻译后、代谢过程和离子信号。在动植物中,胞浆内游离钙离子浓度存在昼夜节律波动,尽管它们的作用还没有完全被描述。我们研究了[Ca~(2+)]Cyt的昼夜振荡是否调节了拟南芥的昼夜振荡。我们报道,在拟南芥中,细胞周期振荡可以通过钙调蛋白-LIKE24(CML24)的钙依赖作用来调节生物钟功能。遗传分析表明,CML24与昼夜节律振荡器之间存在连锁,涉及CAB2 EXPRESSION1(TOC1)的昼夜节律振荡器基因时序。
In the last decade, the view of circadian oscillators has expanded from transcriptional feedback to incorporate post-transcriptional, post-translational, metabolic processes and ionic signalling. In plants and animals, there are circadian oscillations in the concentration of cytosolic-free Ca2+ ([Ca2+]cyt), though their purpose has not been fully characterised. We investigated whether circadian oscillations of [Ca2+]cyt regulate the circadian oscillator of Arabidopsis thaliana. We report that in Arabidopsis, [Ca2+]cyt circadian oscillations can regulate circadian clock function through the Ca2+-dependent action of CALMODULIN-LIKE24 (CML24). Genetic analyses demonstrate a linkage between CML24 and the circadian oscillator, through pathways involving the circadian oscillator gene TIMING OF CAB2 EXPRESSION1 (TOC1).
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