Prefrontal cortex and somatosensory cortex in tactile crossmodal association: an independent component analysis of ERP recordings.
Prefrontal cortex and somatosensory cortex in tactile crossmodal association: an independent component analysis of ERP recordings.
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DOI：
10.1371/journal.pone.0000771
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发表时间：
2007-08-22
期刊：
影响因子：
3.7
通讯作者：
Zhou YD
中科院分区：
文献类型：
--
作者：
Ku Y;Ohara S;Wang L;Lenz FA;Hsiao SS;Bodner M;Hong B;Zhou YD
我们之前对头皮记录的事件相关电位（ERPs）的研究表明，当人类受试者预期视觉刺激和触觉刺激同时到来时，工作记忆任务中触觉振动诱发的体感N140增强。结果表明，这种增强反映了与触觉-视觉跨模关联有关的皮层活动。在本研究中，我们进一步假设这种增强代表了跨模关联中体感皮层和额叶皮层的神经活动。通过对ERP数据进行独立成分分析（ICA），我们发现独立成分（ICs）位于内侧前额叶皮层（前扣带皮层，ACC周围）和初级体感皮层（SI）。大脑皮层中以IC为代表的活动表现出对视觉刺激的预期增强。因此，这种不同的活动表明，大脑皮层参与了与任务相关的跨模态关联。此外，对触觉刺激的相干性分析和格兰杰因果关系谱分析表明，在交叉模态关联中，SI皮层与ACC在触觉刺激的注意和知觉方面表现出合作关系。我们的研究结果以新的证据支持皮层神经生理学的一个重要观点：高级认知操作是从模态特异性感觉皮层（本研究中为SI皮层）发展而来的，它参与各种刺激的感觉和知觉。
Our previous studies on scalp-recorded event-related potentials (ERPs) showed that somatosensory N140 evoked by a tactile vibration in working memory tasks was enhanced when human subjects expected a coming visual stimulus that had been paired with the tactile stimulus. The results suggested that such enhancement represented the cortical activities involved in tactile-visual crossmodal association. In the present study, we further hypothesized that the enhancement represented the neural activities in somatosensory and frontal cortices in the crossmodal association. By applying independent component analysis (ICA) to the ERP data, we found independent components (ICs) located in the medial prefrontal cortex (around the anterior cingulate cortex, ACC) and the primary somatosensory cortex (SI). The activity represented by the IC in SI cortex showed enhancement in expectation of the visual stimulus. Such differential activity thus suggested the participation of SI cortex in the task-related crossmodal association. Further, the coherence analysis and the Granger causality spectral analysis of the ICs showed that SI cortex appeared to cooperate with ACC in attention and perception of the tactile stimulus in crossmodal association. The results of our study support with new evidence an important idea in cortical neurophysiology: higher cognitive operations develop from the modality-specific sensory cortices (in the present study, SI cortex) that are involved in sensation and perception of various stimuli.
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DOI：
10.1073/pnas.0308538101
发表时间：
2004-06-29
影响因子：
11.1
作者：
Brovelli, A;Ding, MZ;Bressler, SL
通讯作者：
Bressler, SL
影响因子：
3.7
作者：
Frot, M;Mauguière, F
通讯作者：
Mauguière, F
影响因子：
6.8
作者：
AKAIKE, H
通讯作者：
AKAIKE, H
影响因子：
4.7
作者：
Eimer, M;Forster, B
通讯作者：
Forster, B
影响因子：
9.2
作者：
Driver, J;Spence, C
通讯作者：
Spence, C