Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering.
Biophysical Stimuli as the Fourth Pillar of Bone Tissue Engineering.
复制标题
生物物理刺激作为骨组织工程的第四支柱
DOI：
10.3389/fcell.2021.790050
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发表时间：
2021
影响因子：
5.5
通讯作者：
Li J
中科院分区：
文献类型：
--
作者：
Hao Z;Xu Z;Wang X;Wang Y;Li H;Chen T;Hu Y;Chen R;Huang K;Chen C;Li J
严重骨缺损的修复在世界范围内仍然是具有挑战性的。骨组织工程的三大支柱(生物材料支架、生物活性分子和干细胞)已被广泛应用于单独或联合策略的骨再生，但生物活性分子的输送存在一些明显的缺陷。生物物理刺激很有可能成为骨组织工程的第四支柱，根据其物理性质可分为三类：内部结构刺激、外部机械刺激和电磁刺激。在这篇综述中，我们首先提出了一些独特的生物物理刺激及其骨诱导窗或参数来诱导间充质干细胞成骨。然后，综述了生物物理转导(机械转导和电偶联)的成骨诱导机制，以指导MSCs的成骨分化。这些机制包括生物物理感知、传输和调节。此外，还介绍了生物物理刺激在骨组织工程中的独特应用策略，包括预先设计的生物材料、组织工程骨移植和术后生物物理刺激加载策略。最后，讨论了当前的挑战和未来的前景。
The repair of critical bone defects remains challenging worldwide. Three canonical pillars (biomaterial scaffolds, bioactive molecules, and stem cells) of bone tissue engineering have been widely used for bone regeneration in separate or combined strategies, but the delivery of bioactive molecules has several obvious drawbacks. Biophysical stimuli have great potential to become the fourth pillar of bone tissue engineering, which can be categorized into three groups depending on their physical properties: internal structural stimuli, external mechanical stimuli, and electromagnetic stimuli. In this review, distinctive biophysical stimuli coupled with their osteoinductive windows or parameters are initially presented to induce the osteogenesis of mesenchymal stem cells (MSCs). Then, osteoinductive mechanisms of biophysical transduction (a combination of mechanotransduction and electrocoupling) are reviewed to direct the osteogenic differentiation of MSCs. These mechanisms include biophysical sensing, transmission, and regulation. Furthermore, distinctive application strategies of biophysical stimuli are presented for bone tissue engineering, including predesigned biomaterials, tissue-engineered bone grafts, and postoperative biophysical stimuli loading strategies. Finally, ongoing challenges and future perspectives are discussed.
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