At the nuclear envelope of bone mechanobiology.
At the nuclear envelope of bone mechanobiology.
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DOI：
10.1016/j.bone.2021.116023
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发表时间：
2021-10
期刊：
影响因子：
4.1
通讯作者：
Uzer G
中科院分区：
文献类型：
--
作者：
Birks S;Uzer G
核被膜和核骨架正在成为信号传导中心，调节细胞外基质的物理信息如何以生化方式转导到细胞核中，影响染色质并控制细胞功能。骨是一种机械驱动的组织，它依赖于物理信息来维持其生理功能和结构。存在肌肉骨骼和心脏症状的疾病，如Emery-Dreifuss肌营养不良症和早衰症，与核膜蛋白的突变相关，包括核骨架和细胞骨架（LINC）复合物的接头，核纤层蛋白A/C和emerin。然而，核被膜机械生物学对骨功能的作用仍有待研究。间充质干细胞（MSC）模型可能是骨调节和核膜功能之间研究最多的关系。间充质干细胞通过分化成包括骨细胞和脂肪细胞在内的多种细胞类型来维持肌肉骨骼系统，从而支持骨骼对机械挑战做出反应的能力。在这篇综述中，我们将重点关注MSC功能是如何调节的机械挑战，在体外和体内的背景下，骨功能，特别是集中在整合素，β-连环蛋白和雅普/TAZ信号。核膜的重要性将在与核膜蛋白突变相关的肌肉骨骼疾病和与骨机械生物学相关的信号通路的核膜调节的背景下在体外和体内进行探索。
The nuclear envelope and nucleoskeleton are emerging as signaling centers that regulate how physical information from the extracellular matrix is biochemically transduced into the nucleus, affecting chromatin and controlling cell function. Bone is a mechanically driven tissue that relies on physical information to maintain its physiological function and structure. Disorder that present with musculoskeletal and cardiac symptoms, such as Emery-Dreifuss muscular dystrophies and progeria, correlate with mutations in nuclear envelope proteins including Linker of Nucleoskeleton and Cytoskeleton (LINC) complex, Lamin A/C, and emerin. However, the role of nuclear envelope mechanobiology on bone function remains underexplored. The mesenchymal stem cell (MSC) model is perhaps the most studied relationship between bone regulation and nuclear envelope function. MSCs maintain the musculoskeletal system by differentiating into multiple cell types including osteocytes and adipocytes, thus supporting the bone’s ability to respond to mechanical challenge. In this review, we will focus on how MSC function is regulated by mechanical challenges both in vitro and in vivo within the context of bone function specifically focusing on integrin, β-catenin and YAP/TAZ signaling. The importance of the nuclear envelope will be explored within the context of musculoskeletal diseases related to nuclear envelope protein mutations and nuclear envelope regulation of signaling pathways relevant to bone mechanobiology in vitro and in vivo.
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影响因子：
2.5
作者：
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