Advances in imaging technologies in the evaluation of high-grade bladder cancer.
Advances in imaging technologies in the evaluation of high-grade bladder cancer.
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DOI：
10.1016/j.ucl.2015.01.001
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发表时间：
2015-05
期刊：
影响因子：
--
通讯作者：
Liao JC
中科院分区：
文献类型：
--
作者：
Zlatev DV;Altobelli E;Liao JC
膀胱癌是一种异质性疾病，范围从具有惰性病程的低级别变异到具有复发性、进行性和潜在致命结果的高级别亚型。个体化治疗的准确评估关键取决于白光膀胱镜检查的诊断准确性。尽管白光膀胱镜检查具有核心作用，但它也存在一些有据可查的缺点，包括难以检测扁平病变、限制完全切除的肿瘤勾画不精确、区分炎症和恶性肿瘤以及分级和分期确定。由于白光膀胱镜检查的局限性增加了癌症持续存在、复发和进展的风险，因此需要改进平坦、多灶性、高级别和肌肉浸润性病变的可视化。光学成像技术已成为白光膀胱镜检查的辅助手段，其目标是通过改善癌症检测和基于分级和分期的患者分层来指导更有效的治疗。光动力诊断和窄带成像是类似于白光膀胱镜检查的宏观成像方式，但提供了膀胱肿瘤的额外对比度增强，并且已被证明可以提高检出率。共焦激光内窥镜和光学相干断层扫描是显微成像技术，能够以类似于组织学的空间分辨率实现实时高分辨率的地下组织表征。分子成像提供了将光学成像技术与癌症特异性分子制剂相结合的潜力，以提高疾病检测的特异性。
Bladder cancer is a heterogeneous disease that ranges from low-grade variant with an indolent course, to high-grade subtype with a recurrent, progressive, and potentially lethal outcome. Accurate assessment for individualized treatment depends critically on the diagnostic accuracy of white light cystoscopy. Despite its central role, white light cystoscopy has several well-documented shortcomings including difficult flat lesion detection, imprecise tumor delineation that limits complete resection, differentiation between inflammation and malignancy, and grade and stage determination. As the limitations of white light cystoscopy contribute to the risk of cancer persistence, recurrence, and progression, there is a need for improved visualization of flat, multifocal, high-grade, and muscle-invasive lesions. Optical imaging technologies have emerged as an adjunct to white light cystoscopy with the goal to guide more effective treatment by improving cancer detection and patient stratification on the basis of grade and stage. Photodynamic diagnosis and narrow band imaging are macroscopic imaging modalities similar to white light cystoscopy, but provide additional contrast enhancement of bladder tumors and have been shown to improve detection rates. Confocal laser endomicroscopy and optical coherence tomography are microscopic imaging technologies that enable real-time high resolution, subsurface tissue characterization with spatial resolutions similar to histology. Molecular imaging offers the potential for the combination of optical imaging technologies with cancer-specific molecular agents to improve the specificity of disease detection.
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DOI：
10.1073/pnas.0906549106
发表时间：
2009-08-18
影响因子：
11.1
作者：
Chan, Keith Syson;Espinosa, Inigo;Weissman, Irving L.
通讯作者：
Weissman, Irving L.
影响因子：
6.6
作者：
Bus, Mieke T. J.;Muller, Berrend G.;de la Rosette, Jean J. M. C. H.
通讯作者：
de la Rosette, Jean J. M. C. H.
影响因子：
4.5
作者：
Herr H;Donat M;Dalbagni G;Taylor J
通讯作者：
Taylor J
多光子显微镜在评估人膀胱活检时。
影响因子：
4.6
作者：
Jain M;Robinson BD;Scherr DS;Sterling J;Lee MM;Wysock J;Rubin MA;Maxfield FR;Zipfel WR;Webb WW;Mukherjee S
通讯作者：
Mukherjee S
影响因子：
23.4
作者：
Brausi, M;Collette, L;Sylvester, RJ
通讯作者：
Sylvester, RJ