Small Nucleolar RNAs and Their Comprehensive Biological Functions in Hepatocellular Carcinoma.
Small Nucleolar RNAs and Their Comprehensive Biological Functions in Hepatocellular Carcinoma.
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核仁小RNA（snoRNA）是一类高度保守、稳定的非编码RNA，参与RNA的转录后修饰和核糖体的生物合成。最近的研究表明snoRNA的功能障碍在肝细胞癌（HCC）和相关病因学中起关键作用，例如肝炎B病毒（HBV）、肝炎C病毒（HCV）和非酒精性脂肪性肝病（NAFLD）。越来越多的证据表明，snoRNA通过多种机制在肝细胞癌（HCC）中充当癌基因或肿瘤抑制因子。此外，snoRNA的特征在于其在体液中的稳定性及其临床相关性，并且代表了作为诊断和预后生物标志物的有前景的工具。SnoRNA代表了癌症研究的一个新兴领域。本文综述了snoRNA的分类、生物起源、活性和功能，并重点介绍了snoRNA在肝癌及相关疾病中的作用机制。我们的发现将有助于理解肿瘤发生和发展的复杂过程，并提出潜在的诊断标志物和治疗靶点。此外，我们还讨论了一些局限性，并提出了未来的研究和应用方向。
Small nucleolar RNAs (snoRNAs) are a class of highly conserved, stable non-coding RNAs involved in both post-transcriptional modification of RNA and in ribosome biogenesis. Recent research shows that the dysfunction of snoRNAs plays a pivotal role in hepatocellular carcinoma (HCC) and related etiologies, such as hepatitis B virus (HBV), hepatitis C virus (HCV), and non-alcoholic fatty liver disease (NAFLD). Growing evidence suggests that snoRNAs act as oncogenes or tumor suppressors in hepatocellular carcinoma (HCC) through multiple mechanisms. Furthermore, snoRNAs are characterized by their stability in body fluids and their clinical relevance and represent promising tools as diagnostic and prognostic biomarkers. SnoRNAs represent an emerging area of cancer research. In this review, we summarize the classification, biogenesis, activity, and functions of snoRNAs, as well as highlight the mechanism and roles of snoRNAs in HCC and related diseases. Our findings will aid in the understanding of complex processes of tumor occurrence and development, as well as suggest potential diagnostic markers and treatment targets. Furthermore, we discuss several limitations and suggest future research and application directions.
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影响因子：
6.1
作者：
Fitz, Nicholas F.;Wang, Jiebiao;Kamboh, M. Ilyas;Koldamova, Radosveta;Lefterov, Iliya
通讯作者：
Lefterov, Iliya
分析肝细胞癌的基因组和转录组鉴定了转化生长因子-β途径中的突变和基因表达变化。
影响因子：
29.4
作者：
Chen J;Zaidi S;Rao S;Chen JS;Phan L;Farci P;Su X;Shetty K;White J;Zamboni F;Wu X;Rashid A;Pattabiraman N;Mazumder R;Horvath A;Wu RC;Li S;Xiao C;Deng CX;Wheeler DA;Mishra B;Akbani R;Mishra L
通讯作者：
Mishra L
SNORNA是一类新型的生物学相关MYC靶标。
影响因子：
5.4
作者：
Herter EK;Stauch M;Gallant M;Wolf E;Raabe T;Gallant P
通讯作者：
Gallant P
影响因子：
82.9
作者：
Friedman SL;Neuschwander-Tetri BA;Rinella M;Sanyal AJ
通讯作者：
Sanyal AJ
鉴定 snoRNA SNORA71A 作为肝细胞癌预后的新型生物标志物
影响因子：
--
作者：
Ding Y;Sun Z;Zhang S;Zhou L;Xu Q;Zhou D;Li Y;Han X;Xu H;Bai Y;Xu C;Ding H;Ge Y;Wang W
通讯作者：
Wang W