Time-in-a-bottle (TIAB): a longitudinal, correlational study of patterns, potential predictors, and outcomes of immunosuppressive medication adherence in adult kidney transplant recipients.
Time-in-a-bottle (TIAB): a longitudinal, correlational study of patterns, potential predictors, and outcomes of immunosuppressive medication adherence in adult kidney transplant recipients.
复制标题
DOI：
10.1111/ctr.12203
复制
发表时间：
2013-09
影响因子：
2.1
通讯作者：
Wakefield MR
中科院分区：
文献类型：
--
作者：
Russell CL;Ashbaugh C;Peace L;Cetingok M;Hamburger KQ;Owens S;Coffey D;Webb AW;Hathaway D;Winsett RP;Madsen R;Wakefield MR
本研究采用基于理论、描述性、相关性、纵向设计，对来自三个肾移植中心的121名年龄≥ 21岁的肾移植受者的免疫抑制药物依从性模式、潜在预测因素和结局进行了研究。使用药物事件监测系统进行电子监测12个月。参与者坚持服用免疫抑制药物，但执行，包括服用和时机，是穷人。年龄较大是与药物依从性相关的唯一人口统计学变量（r = 0.25; p = 0.005）。在潜在的预测因素中，只有药物自我效能与药物不依从性相关，解释了约9%的方差（r = 0.31，p = 0.0006）。发生的少数不良结局与药物不依从性无显著相关性，尽管少数不良结局可能限制了我们检测相关性的能力。未来的研究应该测试充分的动力，基于理论的，实验性的干预措施，包括药物自我效能的组成部分。
This study examined patterns, potential predictors, and outcomes of immunosuppressive medication adherence in a convenience sample of 121 kidney transplant recipients aged 21 years or older from three kidney transplant centers using a theory-based, descriptive, correlational, longitudinal design. Electronic monitoring was conducted for 12 months using the Medication Event Monitoring System. Participants were persistent in taking their immunosuppressive medications, but execution, which includes both taking and timing, was poor. Older age was the only demographic variable associated with medication adherence (r = 0.25; p = 0.005). Of the potential predictors examined, only medication self-efficacy was associated with medication non-adherence, explaining about 9% of the variance (r = 0.31, p = 0.0006). The few poor outcomes that occurred were not significantly associated with medication non-adherence, although the small number of poor outcomes may have limited our ability to detect a link. Future research should test fully powered, theory-based, experimental interventions that include a medication self-efficacy component.
登录
查看更多内容
影响因子：
0.7
作者：
Denhaerynck, Kris;Abraham, Ivo;De Geest, Sabina
通讯作者：
De Geest, Sabina
影响因子：
2.1
作者：
Dharancy, Sebastien;Giral, Magali;Pageaux, Georges-Philippe
通讯作者：
Pageaux, Georges-Philippe
影响因子：
--
作者：
DiMatteo, MR;Lepper, HS;Croghan, TW
通讯作者：
Croghan, TW
影响因子：
8.8
作者：
Fine, R. N.;Becker, Y.;Dobbels, F.
通讯作者：
Dobbels, F.
影响因子：
2.5
作者：
Conn, VS
通讯作者：
Conn, VS