High-density lipoprotein cholesterol efflux capacity is not associated with atherosclerosis and prevalence of cardiovascular outcome: The CODAM study.
High-density lipoprotein cholesterol efflux capacity is not associated with atherosclerosis and prevalence of cardiovascular outcome: The CODAM study.
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DOI：
10.1016/j.jacl.2019.10.012
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发表时间：
2020-01
影响因子：
4.4
通讯作者：
van Greevenbroek MMJ
中科院分区：
文献类型：
--
作者：
Josefs T;Wouters K;Tietge UJF;Annema W;Dullaart RPF;Vaisar T;Arts ICW;van der Kallen CJH;Stehouwer CDA;Schalkwijk CG;Goldberg IJ;Fisher EA;van Greevenbroek MMJ
胆固醇流出能力（CEC）被认为是高密度脂蛋白（HDL）的关键动脉粥样硬化特性。然而，HDL-CEC 在动脉粥样硬化和心血管 (CV) 风险中的作用仍存在争议，并且糖尿病患者的数据有限。在这项研究中，我们研究了心血管疾病 (CVD) 风险升高和 2 型糖尿病 (T2DM) 受试者中 CEC 和其他 HDL 特征与临床和亚临床动脉粥样硬化的关系。使用多元线性回归分析，我们确定了观察队列（CODAM，n = 574，59.6 ± 0.3 年，n = 574，n = 574，n = 574，59.6 ± 0.3 yr， 61.3% 男性，24.4% T2DM）。进行分层分析以确定葡萄糖代谢（NGM）正常的个体和葡萄糖代谢紊乱的个体之间的关联是否存在差异。 HDL-CEC 与动脉粥样硬化标志物（cIMT、EnD 评分）、CVD 或 CVE 均不相关。相比之下，其他 HDL 特征，即 HDL 胆固醇（HDL-C，Z 得分）、载脂蛋白 A-I（apoA-I，Z 得分）、HDL 大小（Z 得分）和 HDL 颗粒数量（HDL-P，Z 得分）与 EnD 得分（s -0.226 至 -0.097，P < .05）和 CVE（ORs）呈显着负相关。 0.61 至 0.68，P < .05）。在分层分析中，HDL 大小和 HDL-P 与 NGM 个体的 EnD 评分显着相关（Pinteraction 分别为 0.039 和 0.005），但在糖尿病（前期）患者中则不然。 HDL-C 和 apoA-I 与糖尿病（前期）患者的 CVD 患病率呈负相关（Pinteraction 分别 = 0.074 和 0.034），但在 NGM 患者中则不然。 HDL-CEC 与临床或亚临床动脉粥样硬化无关，无论是在整个人群中还是在患有（前期）糖尿病的个体中，而其他 HDL 特征显示出动脉粥样硬化相关性。 HDL 大小和 HDL-P 的动脉粥样硬化保护作用在糖尿病（前期）中消失，而 HDL-C 和 apoA-I 浓度较高与糖尿病（前期）中 CVD 患病率较低相关。
Cholesterol Efflux Capacity (CEC) is considered to be a key atheroprotective property of high-density lipoproteins (HDL). However, the role of HDL-CEC in atherosclerosis and cardiovascular (CV) risk is still controversial, and data in individuals with diabetes are limited. In this study, we have investigated the relationship of CEC and other HDL characteristics with clinical and subclinical atherosclerosis in subjects with elevated cardiovascular diseases (CVD) risk and Type 2 Diabetes Mellitus (T2DM). Using multiple linear regression analyses, we determined the relationship of HDL-CEC with carotid intima-media thickness (cIMT, Z-Score), an endothelial dysfunction (EnD) Score (Z-Score), prevalent CVD (n = 150 cases) and history of CV events (CVE, n = 85 cases) in an observational cohort (CODAM, n = 574, 59.6 ± 0.3 yr, 61.3% men, 24.4% T2DM). Stratified analyses were performed to determine if the associations differed between individuals with normal glucose metabolism (NGM) and those with disturbed glucose metabolism. HDL-CEC was not associated with either marker of atherosclerosis (cIMT, EnD Score) nor with CVD or CVE. In contrast, other HDL characteristics that is, HDL-Cholesterol (HDL-C, Z-Score), apolipoprotein A-I (apoA-I, Z-Score), HDL size (Z-Score) and HDL particle number (HDL-P, Z-Score) were inversely and significantly associated with the EnD Score (s −0.226 to −0.097, P < .05) and CVE (ORs 0.61 to 0.68, P < .05). In stratified analyses, HDL size and HDL-P were significantly associated with the EnD Score in individuals with NGM (Pinteraction .039 and .005, respectively), but not in those with (pre)diabetes. HDL-C and apoA-I were inversely associated with prevalent CVD in individuals with (pre)diabetes (Pinteraction = .074 and .034, respectively), but not in those with NGM. HDL-CEC is not associated with clinical or subclinical atherosclerosis, neither in the whole population nor in individuals with (pre)diabetes, while other HDL characteristics show atheroprotective associations. The atheroprotective associations of HDL-size and HDL-P are lost in (pre)diabetes, while higher concentrations of HDL-C and apoA-I are associated with a lower prevalence of CVD in (pre)diabetes.
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DOI：
10.1161/atvbaha.116.307385
发表时间：
2016-05
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Apro J;Tietge UJ;Dikkers A;Parini P;Angelin B;Rudling M
通讯作者：
Rudling M
影响因子：
37.8
作者：
Festa, A;Williams, K;Haffner, SM
通讯作者：
Haffner, SM
影响因子：
5.3
作者：
Assmann, G;Schulte, H;Huang, YD
通讯作者：
Huang, YD
影响因子：
158.5
作者：
Barter, Philip;Gotto, Antonio M.;Fruchart, Jean-Charles
通讯作者：
Fruchart, Jean-Charles
DOI：
10.1006/bbrc.1999.1278
发表时间：
1999-10-22
影响因子：
3.1
作者：
Dimayuga, P;Zhu, J;Cercek, B
通讯作者：
Cercek, B