Translational and Clinical Applications of Dental Stem Cell-Derived Exosomes.
Translational and Clinical Applications of Dental Stem Cell-Derived Exosomes.
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牙干细胞衍生的外泌体的转化和临床应用
DOI：
10.3389/fgene.2021.750990
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发表时间：
2021
影响因子：
3.7
通讯作者：
Zhao X
中科院分区：
文献类型：
--
作者：
Mai Z;Chen H;Ye Y;Hu Z;Sun W;Cui L;Zhao X
骨髓间充质干细胞（Mesenchymal stem cells，MSCs）具有自我更新和多向分化潜能，是组织修复和再生的理想种子细胞。然而，越来越多的证据表明，MSC主要通过分泌exosomes发挥生物学功能。外泌体含有RNA、蛋白质、脂质和代谢物，是调节许多基本过程的新参与者，在再生医学中发挥重要作用。外泌体不仅能模拟其亲本细胞的作用，而且具有许多优点，如高载药量、低免疫原性、良好的生物相容性和低副作用。目前，已分离鉴定出牙髓干细胞（DPSC）、脱落乳牙干细胞（SHED）、牙周膜干细胞（PDLSC）、牙囊祖细胞（DFPCs）、根尖乳头干细胞（SCAPs）和牙龈间充质干细胞（GMSCs）等6种不同的牙源性干细胞。DSC-exosomes（DSC-Exos）在细胞间通讯、抗炎、成骨、血管生成、免疫调节、神经营养和促进肿瘤细胞凋亡等方面发挥重要作用。在这篇综述中，我们将严格审查DSC-Exos的新兴作用和临床应用潜力。
Mesenchymal stem cells (MSCs) are promising seed cells in tissue repair and regeneration due to their featured properties of self-renewal and multipotency. However, a growing body of evidence has demonstrated that MSCs exert biological functions mainly through secreting exosomes. Exosomes, which contain RNA, proteins, lipids, and metabolites, are new players in regulating many fundamental processes and play important roles in regenerative medicine. Exosomes not only mimic the effects of their parent cells but also possess many advantages such as high drug loading capacity, low immunogenicity, excellent biocompatibility, and low side effects. Currently, a total of 6 different dental stem cells (DSCs) including dental pulp stem cells (DPSCs), stem cells from exfoliated deciduous teeth (SHEDs), periodontal ligament stem cells (PDLSCs), dental follicle progenitor cells (DFPCs), stem cells from apical papilla (SCAPs) and gingival mesenchymal stem cells (GMSCs) have been isolated and identified. DSC-derived exosomes (DSC-Exos) are actively involved in intercellular communication, anti-inflammation, osteogenesis, angiogenesis, immunomodulation, nurturing neurons, and promoting tumor cell apoptosis. In this review, we will critically review the emerging role and clinical application potential of DSC-Exos.
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DOI：
10.1126/science.aau6977
发表时间：
2020-02-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kalluri R;LeBleu VS
通讯作者：
LeBleu VS
外泌体作为帕金森氏病疗法的药物。
DOI：
10.1016/j.jconrel.2015.03.033
发表时间：
2015-06-10
期刊：
Journal of controlled release : official journal of the Controlled Release Society
影响因子：
--
作者：
Haney MJ;Klyachko NL;Zhao Y;Gupta R;Plotnikova EG;He Z;Patel T;Piroyan A;Sokolsky M;Kabanov AV;Batrakova EV
通讯作者：
Batrakova EV
影响因子：
8.1
作者：
Imanishi Y;Hata M;Matsukawa R;Aoyagi A;Omi M;Mizutani M;Naruse K;Ozawa S;Honda M;Matsubara T;Takebe J
通讯作者：
Takebe J
影响因子：
4.4
作者：
Ji, Lujun;Bao, Liuliu;Feng, Xingmei
通讯作者：
Feng, Xingmei
影响因子：
1.6
作者：
Jiang, Shengjun;Xu, Liqin
通讯作者：
Xu, Liqin