ABT-263 sensitizes TRAIL-resistant hepatocarcinoma cells by downregulating the Bcl-2 family of anti-apoptotic protein

ABT-263 sensitizes TRAIL-resistant hepatocarcinoma cells by downregulating the Bcl-2 family of anti-apoptotic protein
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ABT-263 通过下调抗凋亡蛋白 Bcl-2 家族来敏化 TRAIL 耐药性肝癌细胞

DOI:
10.1007/s00280-011-1763-0
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发表时间:
2012-03
影响因子:
3
通讯作者:
Li, Wenhua
Li, Wenhua
中科院分区:
医学3区
文献类型:
--
作者:
Wang, Guan;Zhan, Yao;Wang, Haiqing;Li, Wenhua

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目的肿瘤坏死因子相关凋亡诱导配体(tumor necrosis factor-related apoptosis-inducing ligand,TRAIL)对转化细胞具有选择性杀伤作用,是一种很有前途的抗肿瘤药物。然而,大多数人肝细胞癌(HCC)对TRAIL产生抗性。因此,
PurposeTumor necrosis factor–related apoptosis-inducing ligand (TRAIL) is a promising anticancer agent due to its selective cytotoxicity to transformed cells. However, most human hepatocellular carcinomas (HCC) develop resistance to TRAIL. Thus, there is
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