Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease.

Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease.
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DOI:
10.3390/jcdd5010016
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发表时间:
2018-03-08
影响因子:
2.4
通讯作者:
Rentschler SL
Rentschler SL
中科院分区:
医学3区
文献类型:
--
作者:
Lipovsky CE;Brumback BD;Khandekar A;Rentschler SL

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The left and right ventricles of the four-chambered heart have distinct developmental origins and functions. Chamber-specific developmental programming underlies the differential gene expression of ion channel subunits regulating cardiac electrophysiology that persists into adulthood. Here, we discuss regional specific electrical responses to genetic mutations and cardiac stressors, their clinical correlations, and describe many of the multi-scale techniques commonly used to analyze electrophysiological regional heterogeneity.
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