Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge.
Multi-vendor and multisite evaluation of cerebrovascular reactivity mapping using hypercapnia challenge.
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使用高碳酸血症激发进行脑血管反应性标测的多供应商和多中心评价。
DOI：
10.1016/j.neuroimage.2021.118754
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发表时间：
2021-12-15
期刊：
影响因子：
5.7
通讯作者：
Lu H
中科院分区：
文献类型：
--
作者：
Liu P;Jiang D;Albert M;Bauer CE;Caprihan A;Gold BT;Greenberg SM;Helmer KG;Jann K;Jicha G;Rodriguez P;Satizabal CL;Seshadri S;Singh H;Thompson JF;Wang DJJ;Lu H
脑血管反应性（CVR）是大脑血管健康的重要指数，它测量了脑血管对血管活性刺激（例如CO2吸入）的响应（如血管活性刺激）的能力。使用BOLD MRI对CVR进行量化和高碳酸疫虫挑战，在研究和临床研究中表现出了巨大的承诺。但是，为了将其用作大规模和多站点研究中的潜在成像生物标志物，必须检查跨不同MRI获取平台的CO2-CVR定量的可靠性，并且必须检查研究人员/评分者。 MarkVcID小血管疾病生物标志物联盟的该报告的目的是评估三项研究中CO2-CVR定量的可靠性。首先，通过使用基于云的CVR数据处理管道从5个MarkVCID站点中处理相同的30 CVR数据集的评估者，评估了CO2-CVR数据处理的评估者间可靠性。其次，在两个不同供应商的两个扫描仪中，评估了10名年轻受试者的CO2-CVR定量的可重现性。第三，从4个地点的20名老年受试者中评估了重可重复性，扫描间隔少于2周。在所有研究中，使用固定的灵感方法进行了CO2 CVR测量，其中受试者戴着鼻子夹，烟嘴和呼吸的房间空气，以及通过嘴巴袋中包含5％的二氧化碳空气。结果表明，整个脑CVR值的CVR处理评估者COV为0.08±0.08％，在主要大脑区域的0.16％至0.88％之间，所有大脑区域的绝对一致性ICC高于0.9959。发现全脑CVR值的扫描仪COV为6.90±5.08％，在主要大脑区域的4.69％至12.71％之间，这与同一天从相同的扫描仪获得的课内COV相当。两次扫描仪之间一致性的ICC为0.8498，全脑CVR为0.8498，在主要大脑区域的0.8052至0.9185之间。在重测评估中，发现整个脑CVR值的不同日期的重新测试COV为18.29±17.12％，在主要大脑区域的16.58％到19.52％之间，绝对一致性的ICC在0.6480到0.6480到0.77785不等。这些结果表明，在健康志愿者中，良好的评价者，扫描仪和测试可靠性良好，并建议CO2-CVR具有合适的工具特性，可用作多站点和纵向观察研究和临床试验的脑血管功能的成像生物标志物。
Cerebrovascular reactivity (CVR), which measures the ability of cerebral blood vessels to dilate or constrict in response to vasoactive stimuli such as CO2 inhalation, is an important index of the brain’s vascular health. Quantification of CVR using BOLD MRI with hypercapnia challenge has shown great promises in research and clinical studies. However, in order for it to be used as a potential imaging biomarker in large-scale and multi-site studies, the reliability of CO2-CVR quantification across different MRI acquisition platforms and researchers/raters must be examined. The goal of this report from the MarkVCID small vessel disease biomarkers consortium is to evaluate the reliability of CO2-CVR quantification in three studies. First, the inter-rater reliability of CO2-CVR data processing was evaluated by having raters from 5 MarkVCID sites process the same 30 CVR datasets using a cloud-based CVR data processing pipeline. Second, the inter-scanner reproducibility of CO2-CVR quantification was assessed in 10 young subjects across two scanners of different vendors. Third, test-retest repeatability was evaluated in 20 elderly subjects from 4 sites with a scan interval of less than 2 weeks. In all studies, the CO2 CVR measurements were performed using the fixed inspiration method, where the subjects wore a nose clip and a mouthpiece and breathed room air and 5% CO2 air contained in a Douglas bag alternatively through their mouth. The results showed that the inter-rater CoV of CVR processing was 0.08 ± 0.08% for whole-brain CVR values and ranged from 0.16% to 0.88% in major brain regions, with ICC of absolute agreement above 0.9959 for all brain regions. Inter-scanner CoV was found to be 6.90 ± 5.08% for whole-brain CVR values, and ranged from 4.69% to 12.71% in major brain regions, which are comparable to intra-session CoVs obtained from the same scanners on the same day. ICC of consistency between the two scanners was 0.8498 for whole-brain CVR and ranged from 0.8052 to 0.9185 across major brain regions. In the test-retest evaluation, test-retest CoV across different days was found to be 18.29 ± 17.12% for whole-brain CVR values, and ranged from 16.58% to 19.52% in major brain regions, with ICC of absolute agreement ranged from 0.6480 to 0.7785. These results demonstrated good inter-rater, inter-scanner, and test-retest reliability in healthy volunteers, and suggested that CO2-CVR has suitable instrumental properties for use as an imaging biomarker of cerebrovascular function in multi-site and longitudinal observational studies and clinical trials.
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影响因子：
2.5
作者：
Fierstra, Jorn;van Niftrik, Bas;Bozinov, Oliver
通讯作者：
Bozinov, Oliver
影响因子：
3.3
作者：
Blockley, Nicholas P.;Driver, Ian D.;Gowland, Penny A.
通讯作者：
Gowland, Penny A.
影响因子：
4
作者：
Chen JJ;Gauthier CJ
通讯作者：
Gauthier CJ
DOI：
10.1038/jcbfm.2008.109
发表时间：
2009-01
期刊：
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
影响因子：
--
作者：
通讯作者：
--
影响因子：
5.7
作者：
Friedman, Lee;Glover, Gary H.
通讯作者：
Glover, Gary H.