Effects of the psychoactive compounds in green tea on risky decision-making.
Effects of the psychoactive compounds in green tea on risky decision-making.
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绿茶中精神活性化合物对风险决策的影响。
DOI：
10.1097/fbp.0000000000000664
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发表时间：
2022-02-01
影响因子：
1.6
通讯作者：
Simon NW
中科院分区：
文献类型：
--
作者：
Liley AE;Joyner HN;Gabriel DBK;Simon NW
表没食子儿茶素-3-没食子酸酯 (EGCG) 和咖啡因是绿茶中发现的两种主要化合物。虽然 EGCG 具有抗焦虑和抗炎作用，但其对认知的急性影响尚不清楚。此外，尽管绿茶消费广泛，但人们对 EGCG 和咖啡因共同服用如何影响行为知之甚少。在这里，我们研究了多剂量 EGCG 或咖啡因对大鼠冒险模型的影响。这是使用风险决策任务（RDT）进行评估的，其中大鼠在小而安全的奖励和伴随轻度足部电击风险不断增加的大奖励之间进行选择。大鼠急性全身给药 EGCG、咖啡因或联合 EGCG 和咖啡因后进行 RDT 测试。 EGCG 导致冒险行为的剂量依赖性减少，但不影响奖励歧视或任务参与度。咖啡因不会影响冒险行为，但高剂量时会增加运动活动并降低任务参与度。最后，接触 EGCG 和咖啡因对冒险行为没有影响，这表明低剂量的咖啡因足以掩盖 EGCG 引起的风险规避。这些数据表明 EGCG 可以作为治疗诱发强迫性危险决策的心理障碍的潜在治疗方法。
Epigallocatechin-3-gallate (EGCG) and caffeine are the two primary compounds found in green tea. While EGCG has anxiolytic and anti-inflammatory effects, its acute effects on cognition are not well understood. Furthermore, despite widespread green tea consumption, little is known about how EGCG and caffeine co-administration impacts behavior. Here, we investigated effects of multiple doses of either EGCG or caffeine on a rat model of risk-taking. This was assessed using the risky decision-making task (RDT), in which rats choose between a small, safe reward and a large reward with escalating risk of mild footshock. Rats were tested in RDT after acute systemic administration of EGCG, caffeine, or joint EGCG and caffeine. EGCG caused a dose-dependent reduction in risk-taking without affecting reward discrimination or task engagement. Caffeine did not impact risk taking, but elevated locomotor activity and reduced task engagement at high doses. Finally, exposure to both EGCG and caffeine had no effect on risk-taking, suggesting that low-dose caffeine is sufficient to mask the risk-aversion caused by EGCG. These data suggest EGCG as a potential therapeutic treatment for psychological disorders that induce compulsive risky decision-making.
影响因子：
3.1
作者：
Leenaars CHC;Van der Mierden S;Joosten RNJMA;Van der Weide MA;Schirris M;Dematteis M;Meijboom FLB;Feenstra MGP;Bleich A
通讯作者：
Bleich A