Risk-Based Decision Making: A Systematic Scoping Review of Animal Models and a Pilot Study on the Effects of Sleep Deprivation in Rats.
Risk-Based Decision Making: A Systematic Scoping Review of Animal Models and a Pilot Study on the Effects of Sleep Deprivation in Rats.
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DOI：
10.3390/clockssleep3010003
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发表时间：
2021-01-20
期刊：
影响因子：
3.1
通讯作者：
Bleich A
中科院分区：
文献类型：
--
作者：
Leenaars CHC;Van der Mierden S;Joosten RNJMA;Van der Weide MA;Schirris M;Dematteis M;Meijboom FLB;Feenstra MGP;Bleich A
动物，包括人类，经常做出涉及风险或不确定性的决定。根据具体情况，这些决策中的不同策略可能是有利的。睡眠时间短似乎与人类更危险的决定有关。基于风险的决策的动物模型可以增加对机制的理解，但是关于睡眠的影响的数据很少。我们结合了初级研究和元研究来探索动物睡眠和基于风险的决策之间的关系。我们的第一个目标是创建一个概述可用的动物模型的风险决策。我们进行了系统范围审查。我们在Pubmed和Psychinfo中检索到712篇参考文献，其中235篇被纳入。啮齿动物、非人灵长类动物、鸟类、猪和蜜蜂的基于风险的决策动物模型已经被描述。我们讨论了任务设计和模型的有效性。我们的第二个目标是应用这些知识，并对睡眠剥夺的影响进行初步研究。我们训练和测试雄性Wistar大鼠的概率折扣任务;一个“安全”的杠杆总是导致1奖励，一个“风险”的杠杆导致4或没有奖励。大鼠根据奖励概率的变化调整了自己的偏好（p < 0.001），但在光照阶段剥夺12小时的睡眠并没有明显改变风险偏好（p = 0.21）。
Animals, including humans, frequently make decisions involving risk or uncertainty. Different strategies in these decisions can be advantageous depending the circumstances. Short sleep duration seems to be associated with more risky decisions in humans. Animal models for risk-based decision making can increase mechanistic understanding, but very little data is available concerning the effects of sleep. We combined primary- and meta-research to explore the relationship between sleep and risk-based decision making in animals. Our first objective was to create an overview of the available animal models for risky decision making. We performed a systematic scoping review. Our searches in Pubmed and Psychinfo retrieved 712 references, of which 235 were included. Animal models for risk-based decision making have been described for rodents, non-human primates, birds, pigs and honey-bees. We discuss task designs and model validity. Our second objective was to apply this knowledge and perform a pilot study on the effect of sleep deprivation. We trained and tested male Wistar rats on a probability discounting task; a “safe” lever always resulted in 1 reward, a “risky” lever resulted in 4 or no rewards. Rats adapted their preferences to variations in reward probabilities (p < 0.001), but 12 h of sleep deprivation during the light phase did not clearly alter risk preference (p = 0.21).
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影响因子：
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