A rate-based transcutaneous CO2 sensor for noninvasive respiration monitoring.
A rate-based transcutaneous CO2 sensor for noninvasive respiration monitoring.
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DOI：
10.1088/0967-3334/36/5/883
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发表时间：
2015-05
影响因子：
3.2
通讯作者：
Rao G
中科院分区：
文献类型：
--
作者：
Chatterjee M;Ge X;Kostov Y;Luu P;Tolosa L;Woo H;Viscardi R;Falk S;Potts R;Rao G
与用于血气测量的侵入性血液采样相关的疼痛和感染风险需要寻找可靠的非侵入性技术。在这项工作中，我们开发了一种新颖的基于速率的无创方法，用于安全快速地评估呼吸状态。建造了一个小型采样器来收集从皮肤扩散出来的气体。它通过不透气的管道连接到二氧化碳传感器。在测量过程中，首先通过用氮气吹扫取样器来去除最初存在于取样器中的二氧化碳。然后系统中的气体在采样器和 CO2 传感器之间再循环，并测量进入采样器的 CO2 扩散速率。由于测量是基于初始经皮扩散速率，因此不再需要达到传质平衡并加热皮肤，因此比传统方法更快、更安全。进行了一系列设计实验来分析采样器尺寸、测量位置、受试者位置和运动等测量参数的影响。经过因子分析测试后，样机被送往IV级NICU进行临床试验。结果表明，测量的 CO2 分压初始增加率与相应的动脉血气测量值线性相关。新方法可以用作趋势工具，使得呼吸状态监测无需频繁采血。
The pain and risk of infection associated with invasive blood sampling for blood gas measurements necessitate the search for reliable noninvasive techniques. In this work we developed a novel rate-based noninvasive method for a safe and fast assessment of respiratory status. A small sampler was built to collect the gases diffusing out of the skin. It was connected to a CO2 sensor through gas-impermeable tubing. During a measurement, the CO2 initially present in the sampler was first removed by purging it with nitrogen. The gases in the system were then recirculated between the sampler and the CO2 sensor, and the CO2 diffusion rate into the sampler was measured. Because the measurement is based on the initial transcutaneous diffusion rate, reaching mass transfer equilibrium and heating the skin is no longer required, thus, making it much faster and safer than traditional method. A series of designed experiments were performed to analyze the effect of the measurement parameters such as sampler size, measurement location, subject positions, and movement. After the factor analysis tests, the prototype was sent to a level IV NICU for clinical trial. The results show that the measured initial rate of increase in CO2 partial pressure is linearly correlated with the corresponding arterial blood gas measurements. The new approach can be used as a trending tool, making frequent blood sampling unnecessary for respiratory status monitoring.
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影响因子：
--
作者：
Tekade RK;Chougule MB
通讯作者：
Chougule MB
DOI：
10.1097/01.pcc.0000102384.60676.e5
发表时间：
2004-01-01
期刊：
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies
影响因子：
--
作者：
Proquitte, Hans;Krause, Susann;Schmalisch, Gerd
通讯作者：
Schmalisch, Gerd
影响因子：
2.1
作者：
Gannon, CM;Wiswell, TE;Spitzer, AR
通讯作者：
Spitzer, AR
影响因子：
3.8
作者：
Murase, M;Ishida, A
通讯作者：
Ishida, A
DOI：
10.1001/archpedi.1995.02170190027005
发表时间：
1995-06-01
影响因子：
--
作者：
GARLAND, JS;BUCK, RK;LEVITON, A
通讯作者：
LEVITON, A