Genetic Contributions to Lupus‐like Disease in (NZB×NZW)F1 Mice
Genetic Contributions to Lupus‐like Disease in (NZB×NZW)F1 Mice
复制标题
(NZB×NZW)F1 小鼠狼疮样疾病的遗传因素
作者：
C. Drake;S. Rozzo;T. Vyse;E. Palmer;B. Kotzin
系统性红斑狼疮(SLE)是一种病因不明的慢性自身免疫性疾病，其特点是累及多个器官系统，临床表现多样。系统性红斑狼疮的特点是产生针对核成分的自身抗体，包括单链DNA、双链DNA和组蛋白。近90%的狼疮患者是女性，发病率在育龄期间增加，绝经后下降[回顾(Kotzin&O‘Dell，1994)]。对于男性来说，发病高峰期可能要到第七个十年。这些数据表明，性激素在疾病的发展中发挥了作用，雌激素起到了促进作用，雄激素起到了保护作用。系统性红斑狼疮患者的临床病程极不稳定。一些患者病情轻微，自发缓解和消退；另一些患者皮肤和关节受累程度较低，对非类固醇抗炎药物反应良好。还有一些患者遵循更无情的过程，进展到最终器官损害(如肾功能衰竭)，经常伴有多系统受累，对大剂量皮质类固醇和细胞毒性药物无反应。
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease of unknown etiology, characterized by the involvement of multiple organ systems and expression of diverse clinical manifestations. The hallmark of SLE is the production of autoantibodies directed against nuclear components, including ssDNA, dsDNA, and histones. Nearly 90% of lupus patients are female, with incidence increasing during childbearing years and decreasing after menopause [reviewed in (Kotzin & O'Dell 1994)]. For males, peak incidence may not be until the 7th decade of life. These data suggest a role for sex hormones in the development of disease, with estrogens exerting an enhancing effect and androgens a protective influence. The clinical course of patients with SLE is extremely variable. Some patients have mild forms of disease, with spontaneous remissions and regressions; others demonstrate low levels of skin and joint involvement and respond favorably to nonsteroidal anti-inflammatory medications. Still other patients follow a more relentless course, progressing to end organ damage (such as renal failure) frequently with multisystem involvement, in a manner unresponsive to high doses of corticosteroids and cytotoxic drugs.
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影响因子：
4.4
作者：
D. Wofsy
通讯作者：
D. Wofsy
影响因子：
32.4
作者：
MOREL, L;RUDOFSKY, UH;WAKELAND, EK
通讯作者：
WAKELAND, EK
影响因子：
32.4
作者：
LYNCH, DH;WATSON, ML;SELDIN, MF
通讯作者：
SELDIN, MF
评估由 bm12 突变定义的 Ia 分子上的抗原特异性限制位点。
DOI：
--
发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Kanamori,S;Walsh,WD;Hansen,TH;Tse,HY
通讯作者：
Tse,HY
NZB.H-2bm12 小鼠中的 BM12 突变和 dsDNA 自身抗体。
DOI：
--
发表时间：
1990
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Chiang,BL;Bearer,E;Ansari,A;Dorshkind,K;Gershwin,ME
通讯作者：
Gershwin,ME