MTFR2 shapes a barrier of immune microenvironment in hepatocellular carcinoma.
MTFR2 shapes a barrier of immune microenvironment in hepatocellular carcinoma.
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MTFR2在肝细胞癌中形成免疫微环境屏障
DOI：
10.1016/j.isci.2022.105095
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发表时间：
2023-01-20
期刊：
影响因子：
5.8
通讯作者：
Shen, Hong
中科院分区：
文献类型：
--
作者：
Huang, Qiaoqiao;Han, Ying;Shen, Edward;Feng, Ziyang;Peng, Yinghui;Gao, Le;Gao, Yan;Yu, Yongtin;Li, Wei;Liu, Ping;Guo, Cao;Zeng, Shan;Cai, Changjing;Shen, Hong
肝细胞癌（HCC）是全球癌症相关死亡的主要原因。线粒体分裂调节因子2（MTFR2）参与多种癌症的发生发展。然而，MTFR2在肝细胞癌中的作用仍不明确。在本研究中，我们对肝细胞癌中的MTFR2进行了全面分析，该分析是基于对8种肝细胞癌细胞系以及来自大量肝细胞癌组织、生存和免疫治疗数据的3个数据集（公共数据集、真实世界数据集和免疫治疗数据集）的综合MTFR2分析而得出的。我们证明MTFR2在肝细胞癌中的表达水平上调，导致预后不良。MTFR2与免疫细胞浸润水平、多个免疫检查点以及免疫治疗反应预测通路呈正相关，并且在癌症 - 免疫循环中起重要作用。总之，我们的研究表明MTFR2可形成免疫微环境的屏障，导致肝细胞癌预后不良，但免疫疗法可能打破这一免疫屏障。
MTFR2在肝细胞癌中上调，导致患者的总生存期（OS）缩短和无病生存期（DFS）变差
MTFR2与免疫细胞浸润水平和免疫检查点呈正相关
MTFR2可能在癌症 - 免疫循环中起重要作用
MTFR2可形成免疫微环境的屏障，但可能被免疫疗法打破
生物科学；癌症；免疫学
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death in the world. Mitochondrial fission regulator 2 (MTFR2) is involved in the development of various cancers. However, the roles of MTFR2 in HCC remain unknown. In this study, we conducted a comprehensive analysis of MTFR2 in HCC, which was generated from integrative MTFR2 analyses of eight HCC cell lines, and three datasets (public dataset, real-world dataset, and immunotherapy dataset) derived from bulk HCC tissues, survival, and immunotherapy data. We demonstrated that the expression level of MTFR2 is upregulated in HCC, leading to poor prognosis. MTFR2 is positively correlated with the level of immune cell infiltration, multiple immune checkpoints and immunotherapy response prediction pathways, and acts as an important role in cancer-immunity cycle. In conclusion, our work indicates that MTFR2 can shape a barrier of immune microenvironment and result in poor prognosis in hepatocellular carcinoma, but the immune barrier may be broken by immunotherapy. MTFR2 is upregulated in HCC, leading to shorter OS and worse DFS in patients MTFR2 is positively related with immune cell infiltration level and immune checkpoints MTFR2 may act as an important role in cancer-immunity cycle MTFR2 can shape a barrier of immune microenvironment, but may be broken by immunotherapy Biological sciences; Cancer; Immunology
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