Clustering of spontaneous recurrent seizures separated by long seizure-free periods: An extended video-EEG monitoring study of a pilocarpine mouse model.
Clustering of spontaneous recurrent seizures separated by long seizure-free periods: An extended video-EEG monitoring study of a pilocarpine mouse model.
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DOI：
10.1371/journal.pone.0194552
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发表时间：
2018
期刊：
影响因子：
3.7
通讯作者：
Lee SK
中科院分区：
文献类型：
--
作者：
Lim JA;Moon J;Kim TJ;Jun JS;Park B;Byun JI;Sunwoo JS;Park KI;Lee ST;Jung KH;Jung KY;Kim M;Jeon D;Chu K;Lee SK
癫痫聚集性发作是癫痫患者中常见而重要的现象。在包括小鼠匹罗卡品模型在内的癫痫动物模型中，自发性反复发作（SRS）的聚集性已被报道。然而，大多数研究分析了癫痫持续状态（SE）诱导后的短期癫痫发作。在这项研究中，我们研究了详细的特点，在慢性阶段的小鼠匹罗卡品诱导的癫痫模型的持续时间延长，连续24/7视频脑电图监测癫痫发作群集。癫痫发作群集定义为至少连续三天每天发生一次或多次癫痫发作，并且在群集期间至少发生五次癫痫发作。我们分析了群集持续时间、无癫痫发作期、群集间隔以及群集内和群集外的癫痫发作次数。诱发SE后84.5±33.7天开始进行视频脑电图监测，持续时间为53.7±20.4天。每只小鼠均表现出癫痫发作簇，97.0%的癫痫发作发生在一个簇期内。癫痫簇发作之后是16.3±6.8天的长无癫痫期，显示出周期性模式。SRS也在一天内以分组模式发生。我们证明，几乎所有的癫痫发作发生在集群与周期性模式在慢性阶段的小鼠匹罗卡品诱导的癫痫模型。集群之间的无干扰期很长。当使用该动物模型进行体内研究时，应考虑这些发现。此外，该模型可能适用于研究未揭示的发病机制。
Seizure clustering is a common and significant phenomenon in patients with epilepsy. The clustering of spontaneous recurrent seizures (SRSs) in animal models of epilepsy, including mouse pilocarpine models, has been reported. However, most studies have analyzed seizures for a short duration after the induction of status epilepticus (SE). In this study, we investigated the detailed characteristics of seizure clustering in the chronic stage of a mouse pilocarpine-induced epilepsy model for an extended duration by continuous 24/7 video-EEG monitoring. A seizure cluster was defined as the occurrence of one or more seizures per day for at least three consecutive days and at least five seizures during the cluster period. We analyzed the cluster duration, seizure-free period, cluster interval, and numbers of seizures within and outside the seizure clusters. The video-EEG monitoring began 84.5±33.7 days after the induction of SE and continued for 53.7±20.4 days. Every mouse displayed seizure clusters, and 97.0% of the seizures occurred within a cluster period. The seizure clusters were followed by long seizure-free periods of 16.3±6.8 days, showing a cyclic pattern. The SRSs also occurred in a grouped pattern within a day. We demonstrate that almost all seizures occur in clusters with a cyclic pattern in the chronic stage of a mouse pilocarpine-induced epilepsy model. The seizure-free periods between clusters were long. These findings should be considered when performing in vivo studies using this animal model. Furthermore, this model might be appropriate for studying the unrevealed mechanism of ictogenesis.
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DOI：
10.1523/jneurosci.0980-08.2009
发表时间：
2009-02-18
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Williams PA;White AM;Clark S;Ferraro DJ;Swiercz W;Staley KJ;Dudek FE
通讯作者：
Dudek FE
影响因子：
2.2
作者：
Citraro, Rita;Scicchitano, Francesca;Russo, Emilio
通讯作者：
Russo, Emilio
影响因子：
5.6
作者：
Ferastraoaru, Victor;Schulze-Bonhage, Andreas;Haut, Sheryl R.
通讯作者：
Haut, Sheryl R.
影响因子：
2.2
作者：
Arida, RM;Scorza, FA;Cavalheiro, EA
通讯作者：
Cavalheiro, EA
影响因子：
2.2
作者：
Löscher, W
通讯作者：
Löscher, W