Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized (129)Xe MRI.
Damaged lung gas exchange function of discharged COVID-19 patients detected by hyperpolarized (129)Xe MRI.
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DOI：
10.1126/sciadv.abc8180
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发表时间：
2021-01
期刊：
影响因子：
13.6
通讯作者：
Zhou X
中科院分区：
文献类型：
--
作者：
Li H;Zhao X;Wang Y;Lou X;Chen S;Deng H;Shi L;Xie J;Tang D;Zhao J;Bouchard LS;Xia L;Zhou X
COVID-19患者中肺的功能成像显示出气体交换功能的改变。
COVID-19患者的恢复过程尚不清楚。一些康复的患者抱怨持续的呼吸急促。在Covid-19中已经报道了Vasculopathy，这强调了探测肺泡毛细管界面上肺微结构和功能的重要性。尽管计算机断层扫描（CT）检测到结构异常，但对疾病对肺功能的影响知之甚少。 129XE磁共振成像（MRI）是一种能够评估通风，微观结构和气体交换的技术。使用129XE MRI，我们发现Covid-19患者的通风缺陷率（5.9％v 3.7％），未改变的微观结构和更长的气体交换时间（43.5 ms对32.5 ms）与健康个体相比。这些发现表明，放电时间内，区域通风和肺泡空域尺寸相对正常，而气血交换功能则降低。这项研究确定了COVID-19患者中局部肺功能测量的可行性及其作为补充结构成像的潜在有用性。
Functional imaging of the lungs in COVID-19 patients shows altered gas exchange function. The recovery process of COVID-19 patients is unclear. Some recovered patients complain of continued shortness of breath. Vasculopathy has been reported in COVID-19, stressing the importance of probing pulmonary microstructure and function at the alveolar-capillary interface. While computed tomography (CT) detects structural abnormalities, little is known about the impact of disease on lung function. 129Xe magnetic resonance imaging (MRI) is a technique uniquely capable of assessing ventilation, microstructure, and gas exchange. Using 129Xe MRI, we found that COVID-19 patients show a higher rate of ventilation defects (5.9% versus 3.7%), unchanged microstructure, and longer gas-blood exchange time (43.5 ms versus 32.5 ms) compared with healthy individuals. These findings suggest that regional ventilation and alveolar airspace dimensions are relatively normal around the time of discharge, while gas-blood exchange function is diminished. This study establishes the feasibility of localized lung function measurements in COVID-19 patients and their potential usefulness as a supplement to structural imaging.
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DOI：
10.1016/s0140-6736(03)13364-8
发表时间：
2003-05-17
期刊：
Lancet (London, England)
影响因子：
--
作者：
Hon KL;Leung CW;Cheng WT;Chan PK;Chu WC;Kwan YW;Li AM;Fong NC;Ng PC;Chiu MC;Li CK;Tam JS;Fok TF
通讯作者：
Fok TF
影响因子：
158.5
作者：
Ackermann, Maximilian;Verleden, Stijn E.;Jonigk, Danny
通讯作者：
Jonigk, Danny
影响因子：
19.7
作者：
Driehuys, Bastiaan;Martinez-Jimenez, Santiago;McAdams, H. Page
通讯作者：
McAdams, H. Page
影响因子：
3.3
作者：
Stewart, Neil J.;Leung, General;Wild, Jim M.
通讯作者：
Wild, Jim M.
影响因子：
10.6
作者：
Tustison NJ;Avants BB;Cook PA;Zheng Y;Egan A;Yushkevich PA;Gee JC
通讯作者：
Gee JC