Considerations for a Respiratory Syncytial Virus Vaccine Targeting an Elderly Population.
Considerations for a Respiratory Syncytial Virus Vaccine Targeting an Elderly Population.
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DOI：
10.3390/vaccines9060624
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发表时间：
2021-06-09
期刊：
影响因子：
7.8
通讯作者：
Varga SM
中科院分区：
文献类型：
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作者：
Stephens LM;Varga SM
呼吸道合胞病毒（RSV）最常与婴儿和儿童的急性下呼吸道感染相关。然而，RSV也会导致老年人的高疾病负担，这一点往往未被认识到。在美国，65岁以上的成年人每年估计有80，000例RSV相关住院治疗和14，000例死亡。RSV感染老年人可导致更严重的疾病症状，包括肺炎和细支气管炎。鉴于RSV在老年人中造成的巨大疾病负担，该人群仍然是疫苗开发的重要目标。衰老导致免疫反应性降低，其特征在于先天免疫和适应性免疫两者的损伤。这种免疫衰老在开发针对老年人的疫苗时构成了挑战。针对老年人群定制的RSV疫苗将需要最大化引发的免疫应答，以克服免疫系统中与年龄相关的缺陷。在这篇文章中，我们回顾了成功开发用于老年人的RSV疫苗必须克服的障碍，并讨论了目前在这一高度易感人群中测试的候选疫苗。
Respiratory syncytial virus (RSV) is most commonly associated with acute lower respiratory tract infections in infants and children. However, RSV also causes a high disease burden in the elderly that is often under recognized. Adults >65 years of age account for an estimated 80,000 RSV-associated hospitalizations and 14,000 deaths in the United States annually. RSV infection in aged individuals can result in more severe disease symptoms including pneumonia and bronchiolitis. Given the large disease burden caused by RSV in the aged, this population remains an important target for vaccine development. Aging results in lowered immune responsiveness characterized by impairments in both innate and adaptive immunity. This immune senescence poses a challenge when developing a vaccine targeting elderly individuals. An RSV vaccine tailored towards an elderly population will need to maximize the immune response elicited in order to overcome age-related defects in the immune system. In this article, we review the hurdles that must be overcome to successfully develop an RSV vaccine for use in the elderly, and discuss the vaccine candidates currently being tested in this highly susceptible population.
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影响因子：
7.8
作者：
Briceno, Olivia;Lissina, Anna;Appay, Victor
通讯作者：
Appay, Victor
DOI：
10.1056/nejmoa2035389
发表时间：
2021-02-04
期刊：
The New England journal of medicine
影响因子：
--
作者：
Baden LR;El Sahly HM;Essink B;Kotloff K;Frey S;Novak R;Diemert D;Spector SA;Rouphael N;Creech CB;McGettigan J;Khetan S;Segall N;Solis J;Brosz A;Fierro C;Schwartz H;Neuzil K;Corey L;Gilbert P;Janes H;Follmann D;Marovich M;Mascola J;Polakowski L;Ledgerwood J;Graham BS;Bennett H;Pajon R;Knightly C;Leav B;Deng W;Zhou H;Han S;Ivarsson M;Miller J;Zaks T;COVE Study Group
通讯作者：
COVE Study Group
DOI：
10.1186/1742-4933-7-14
发表时间：
2010-10-20
期刊：
Immunity & ageing : I & A
影响因子：
--
作者：
Cusi MG;Martorelli B;Di Genova G;Terrosi C;Campoccia G;Correale P
通讯作者：
Correale P
影响因子：
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作者：
Cherukuri, Anu;Patton, Kathryn;Tang, Roderick S.
通讯作者：
Tang, Roderick S.
影响因子：
82.9
作者：
通讯作者：
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