MAIT Cells and Microbiota in Multiple Sclerosis and Other Autoimmune Diseases.
MAIT Cells and Microbiota in Multiple Sclerosis and Other Autoimmune Diseases.
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DOI：
10.3390/microorganisms9061132
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发表时间：
2021-05-24
期刊：
影响因子：
4.5
通讯作者：
Ristori G
中科院分区：
文献类型：
--
作者：
Mechelli R;Romano S;Romano C;Morena E;Buscarinu MC;Bigi R;Bellucci G;Reniè R;Pellicciari G;Salvetti M;Ristori G
在稳态条件下，粘膜相关的不变性T （MAIT）细胞的功能包括与微生物群及其产物的相互作用，保护身体屏障，以及对损伤或感染的组织修复反应。MAIT细胞功能障碍和生态失调常见于炎性、代谢性和肿瘤性慢性疾病。本综述旨在分析多发性硬化症和其他自身免疫性疾病中MAIT细胞以及微生物群的变化。在这些情况下，生态失调的共同特征是微生物种类丰富度降低，肠道微生物群的促炎和免疫调节成分之间不平衡。关于MAIT细胞在这些疾病中的作用的文献相当复杂，有时不一致。在多发性硬化症和其他自身免疫性疾病中，一些研究已经完成或正在进行，以发现治疗和treatment-naïve患者肠道通透性、生态失调、MAIT细胞反应和临床生物标志物之间的相关性。最终目的是解释在非主要感染性疾病中是什么激活了MAIT细胞，哪些与微生物群的相互作用具有潜在的致病性，以及它们与疾病进程和疾病修饰治疗相关的动态。
The functions of mucosal-associated invariant T (MAIT) cells in homeostatic conditions include the interaction with the microbiota and its products, the protection of body barriers, and the mounting of a tissue-repair response to injuries or infections. Dysfunction of MAIT cells and dysbiosis occur in common chronic diseases of inflammatory, metabolic, and tumor nature. This review is aimed at analyzing the changes of MAIT cells, as well as of the microbiota, in multiple sclerosis and other autoimmune disorders. Common features of dysbiosis in these conditions are the reduced richness of microbial species and the unbalance between pro-inflammatory and immune regulatory components of the gut microbiota. The literature concerning MAIT cells in these disorders is rather complex, and sometimes not consistent. In multiple sclerosis and other autoimmune conditions, several studies have been done, or are in progress, to find correlations between intestinal permeability, dysbiosis, MAIT cell responses, and clinical biomarkers in treated and treatment-naïve patients. The final aims are to explain what activates MAIT cells in diseases not primarily infective, which interactions with the microbiota are potentially pathogenic, and their dynamics related to disease course and disease-modifying treatments.
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影响因子：
7.3
作者：
Chiba A;Murayama G;Miyake S
通讯作者：
Miyake S
DOI：
10.1126/science.aax6624
发表时间：
2019-10-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Constantinides MG;Link VM;Tamoutounour S;Wong AC;Perez-Chaparro PJ;Han SJ;Chen YE;Li K;Farhat S;Weckel A;Krishnamurthy SR;Vujkovic-Cvijin I;Linehan JL;Bouladoux N;Merrill ED;Roy S;Cua DJ;Adams EJ;Bhandoola A;Scharschmidt TC;Aubé J;Fischbach MA;Belkaid Y
通讯作者：
Belkaid Y
影响因子：
3.7
作者：
Alam, Jehan;Lee, Ahreum;Choi, Youngnim
通讯作者：
Choi, Youngnim
影响因子：
7.3
作者：
Acquaviva, Massimo;Bassani, Claudia;Farina, Cinthia
通讯作者：
Farina, Cinthia
影响因子：
64.5
作者：
Duscha, Alexander;Gisevius, Barbara;Haghikia, Aiden
通讯作者：
Haghikia, Aiden