A natural reassortant and mutant serotype 3 reovirus from mink in China.

A natural reassortant and mutant serotype 3 reovirus from mink in China.
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来自中国水貂的自然重配和突变型3血清型呼肠孤病毒

DOI:
10.1007/s00705-015-2670-1
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发表时间:
2016-02
影响因子:
2.7
通讯作者:
Hu RL
Hu RL
中科院分区:
医学4区
文献类型:
--
作者:
Zhang YW;Liu Y;Lian H;Zhang F;Zhang SF;Hu RL

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哺乳动物正呼肠孤病毒 (MRV) 分布广泛,几乎感染所有哺乳动物。我们在此报告了中国首例来自水貂的自然突变和重配血清型 3 呼肠孤病毒,称为 MRV3 SD-14。全基因组序列分析表明,MRV3 SD-14 可能是感染猪、人类和水貂的 MRV 重组的结果。有趣的是,编码病毒附着蛋白σ1(影响病毒毒力和宿主细胞向性)的S1片段在氨基酸246处有一个终止密码子突变。对人类和其他动物中MRV毒力和进化的监测值得更多关注。
Mammalian orthoreoviruses (MRVs) are widespread and infect virtually all mammals. We report here the first case of a natural mutant and reassortant serotype 3 reovirus from mink in China, known as MRV3 SD-14. Whole-genome sequence analysis showed that the MRV3 SD-14 may have resulted from a reassortment involving MRVs that infected swine, humans and mink. Interestingly, the S1 segment, which encodes the viral attachment protein σ1, which influences viral virulence and cell tropism in the host, had a stop codon mutation at amino acid 246. Surveillance of the virulence and evolution of MRVs in humans and other animals deserves more attention.
DOI: 10.1006/bbrc.2001.5612
发表时间: 2001-09-21
影响因子: 3.1
作者:
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期刊: GENE THERAPY
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