Animal models of insulin resistance and heart failure.
Animal models of insulin resistance and heart failure.
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DOI：
10.1007/s10741-013-9387-6
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发表时间：
2014-01
影响因子：
4.6
通讯作者：
Sabbah, Hani N.
中科院分区：
文献类型：
--
作者：
Velez, Mauricio;Kohli, Smita;Sabbah, Hani N.
关键词：
心力衰竭（HF）和糖尿病的发病率迅速增加，并与预后不良有关。尽管在治疗方面取得了进展，HF仍然是具有高发病率和死亡率的主要健康问题。当HF和糖尿病共存时，临床结局显著更差。这两个条件之间的关系已经在各种实验模型中进行了研究。然而，这种相互关系的机制是复杂的，不完全理解，并已成为一个相当大的临床和研究兴趣的问题。只有少数动物模型同时表现出HF和糖尿病。然而，将这些模型的结果转化为人类疾病是有限的，需要新的模型来扩展我们目前对这种临床相互作用的理解。本文就胰岛素信号转导和胰岛素抵抗的机制、胰岛素抵抗与心力衰竭的临床关系及其可能的病理生理机制作一综述。最后，我们讨论了现有的胰岛素抵抗和HF的动物模型，并提出了未来新模型的要求。
The incidence of heart failure (HF) and diabetes mellitus is rapidly increasing and is associated with poor prognosis. In spite of the advances in therapy, HF remains a major health problem with high morbidity and mortality. When HF and diabetes coexist, clinical outcomes are significantly worse. The relationship between these two conditions has been studied in various experimental models. However, the mechanisms for this interrelationship are complex, incompletely understood, and have become a matter of considerable clinical and research interest. There are only few animal models that manifest both HF and diabetes. However, the translation of results from these models to human disease is limited and new models are needed to expand our current understanding of this clinical interaction. In this review, we discuss mechanisms of insulin signaling and insulin resistance, the clinical association between insulin resistance and HF and its proposed pathophysiologic mechanisms. Finally, we discuss available animal models of insulin resistance and HF and propose requirements for future new models.
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