Lineage specifiers: new players in the induction of pluripotency.
Lineage specifiers: new players in the induction of pluripotency.
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DOI：
10.1016/j.gpb.2013.09.005
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发表时间：
2013-10
影响因子：
9.5
通讯作者：
Deng, Hongkui
中科院分区：
文献类型：
--
作者：
Shu, Jian;Deng, Hongkui
多能性相关因子和它们的竞争者谱系特异性因子长期以来被认为分别是多能性和分化细胞的身份的决定因素。因此，用于细胞重编程以诱导多能性的因子主要从胚胎干细胞（ESC）富集的和多能性相关的因子中鉴定。最近，谱系说明符已被确定为在协调恢复多能性的过程中发挥重要作用。在这篇综述中，我们总结了最新的发现，关于细胞命运转换使用多能性相关因子和谱系说明。我们强调了“跷跷板”模型在定义细胞身份方面的价值，开辟了一个新的场景来考虑多能性和谱系规范。
Pluripotency-associated factors and their rivals, lineage specifiers, have long been considered the determining factors for the identity of pluripotent and differentiated cells, respectively. Therefore, factors that are employed for cellular reprogramming in order to induce pluripotency have been identified mainly from embryonic stem cell (ESC)-enriched and pluripotency-associated factors. Recently, lineage specifiers have been identified to play important roles in orchestrating the process of restoring pluripotency. In this review, we summarize the latest discoveries regarding cell fate conversion using pluripotency-associated factors and lineage specifiers. We highlight the value of the “seesaw” model in defining cellular identity, opening up a novel scenario to consider pluripotency and lineage specification.
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影响因子：
64.5
作者：
Thomson M;Liu SJ;Zou LN;Smith Z;Meissner A;Ramanathan S
通讯作者：
Ramanathan S
影响因子：
64.5
作者：
Young RA
通讯作者：
Young RA
通过确定的因素将成纤维细胞直接转化为功能性神经元。
影响因子：
64.8
作者：
Vierbuchen, Thomas;Ostermeier, Austin;Pang, Zhiping P.;Kokubu, Yuko;Suedhof, Thomas C.;Wernig, Marius
通讯作者：
Wernig, Marius
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23.9
作者：
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影响因子：
21.3
作者：
Feng, Bo;Jiang, Jianming;Ng, Huck-Hui
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Ng, Huck-Hui