The Association of Cox-2 Genotypes with Pterygium Formation in Taiwan
The Association of Cox-2 Genotypes with Pterygium Formation in Taiwan
复制标题
Cox-2 基因型与台湾翼状胬肉形成的关联
DOI：
10.4247/am.2011.aba013
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发表时间：
2011
影响因子：
2.5
通讯作者：
Ru
中科院分区：
文献类型：
--
作者：
Chia;Ching;P. Hsu;Wen;Cheng;Song;Shung‐Shung Sun;Y. Shih;Chia‐Wen Tsai;D. Bau;Ru
环氧化酶2（考克斯-2）基因和翼状胬肉形成之间的关系还不清楚。本研究旨在探讨考克斯-2基因多态性与翼状胬肉形成的相关性及相互作用。从台湾中部的彰化医院招募了113名翼状胬肉患者和400名健康对照者（无翼状胬肉），通过聚合酶链反应和限制性片段长度多态性（PCR-RFLP）进行基因分型。从NCBI网站上选取考克斯-2基因G-1195 A、G-765 C、T+8473 C、内含子1、内含子5、内含子6等6个多态性位点，分析其基因型与翼状胬肉易感性的关系。结果显示，考克斯-2基因G-1195 A、G-765 C、T+8473 C、内含子1、内含子5、内含子6在翼状胬肉组和对照组之间的分布差异均无统计学意义（P>0.05）。这些结果表明，考克斯-2可能只有转录后或翻译后调节翼状胬肉的形成，而不是在遗传水平。
The relationship between the cyclooxygenase 2 (Cox-2) gene and pterygium formation is not well understood. In this study, the association and interaction between genotypic polymorphisms in Cox-2 gene and pterygium formation were investigated. 113 patients with pterygium and 400 healthy controls (without pterygium) enrolled from the Chang-Hwa hospital in central Taiwan were genotyped by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP). Six polymorphic variants of Cox-2 were selected from the NCBI website and investigated, including G-1195A, G- 765C, T+8473C, intron 1, intron 5, and intron 6, and the association of specific genotypes with susceptibility to pterygium was analyzed. The data showed that, none of the Cox-2 G-1195A, G-765C, T+8473C, intron 1, intron 5, and intron 6 were found to have difference in the distribution between the pterygium and the control groups (P＞0.05). These findings suggest that, Cox-2 may have only post-transcriptional or post-translational regulatory effects on pterygium formation, not at the genetic level.
cyclooxygenase-2 在皮肤癌发生中重要吗？
DOI：
--
发表时间：
2002
期刊：
Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
影响因子：
--
作者：
Fischer,SusanM
通讯作者：
Fischer,SusanM
影响因子：
--
作者：
Dushku, N;John, MK;Reid, TW
通讯作者：
Reid, TW