Levels of PAH-DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population.
Levels of PAH-DNA adducts in placental tissue and the risk of fetal neural tube defects in a Chinese population.
复制标题
胎盘组织中PAH-DNA加合物的水平以及中国人群中胎儿神经管缺陷的风险。
DOI：
10.1016/j.reprotox.2013.01.008
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发表时间：
2013-06
期刊：
影响因子：
--
通讯作者：
Ren A
中科院分区：
文献类型：
--
作者：
Yuan Y;Jin L;Wang L;Li Z;Zhang L;Zhu H;Finnell RH;Zhou G;Ren A
我们研究了胎盘组织中PAH-DNA加合物水平与胎儿神经管缺陷（NTDs）风险之间的关系，这种关系是通过高度敏感的32p标记后测定法测量的。我们进一步探讨了多环芳烃dna加合物和胎盘多环芳烃与NTD风险之间的相互作用。本病例对照研究纳入了80例ntd感染妊娠和50例正常妊娠的胎盘组织。NTD组的PAH-DNA加合物水平（每108个核苷酸8.12个）低于对照组（每108个核苷酸9.92个）。PAH-DNA加合物浓度低于中位数与NTD风险增加3倍相关。低多环芳烃dna加合物水平与高胎盘多环芳烃水平相一致的妇女导致ntd并发症妊娠的风险增加10倍。胎盘PAH-DNA加合物的低水平与ntd的风险增加有关；当低加合物水平与高胎盘多环芳烃浓度相结合时，这种风险急剧增加。
We examined the relationship between PAH-DNA adduct levels in the placental tissue, measured by a highly sensitive 32P-postlabeling assay, and the risk of fetal neural tube defects (NTDs). We further explored the interaction between PAH-DNA adducts and placental PAHs with respect to NTD risk. Placental tissues from 80 NTD-affected pregnancies and 50 uncomplicated normal pregnancies were included in this case-control study. Levels of PAH-DNA adducts were lower in the NTD group (8.12 per 108 nucleotides) compared to controls (9.92 per 108 nucleotides). PAH-DNA adduct concentrations below the median was associated with a 3-fold increased NTD risk. Women with a low PAH-DNA adduct level in concert with a high placental PAH level resulted in a 10-fold elevated risk of having an NTD-complicated pregnancy. A low level of placental PAH-DNA adducts was associated with an increased risk of NTDs; this risk increased dramatically when a low adduct level was coupled with a high placental PAH concentration.
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影响因子：
8.3
作者：
Sagiv, Sharon K.;Gaudet, Mia M.;Eng, Sybil M.;Abrahamson, Page E.;Shantakumar, Sumitra;Teitelbaum, Susan L.;Bell, Paula;Thomas, Joyce A.;Neugut, Alfred I.;Santella, Regina M.;Gammon, Marilie D.
通讯作者：
Gammon, Marilie D.
在国家出生缺陷的预防研究中，母体职业暴露于多环芳族烃和先天性心脏缺陷。
DOI：
10.1002/bdra.23071
发表时间：
2012-11
期刊：
Birth defects research. Part A, Clinical and molecular teratology
影响因子：
--
作者：
Lupo PJ;Symanski E;Langlois PH;Lawson CC;Malik S;Gilboa SM;Lee LJ;Agopian AJ;Desrosiers TA;Waters MA;Romitti PA;Correa A;Shaw GM;Mitchell LE;National Birth Defects Prevention Study
通讯作者：
National Birth Defects Prevention Study
影响因子：
11.2
作者：
Rybicki, BA;Rundle, A;Tang, DL
通讯作者：
Tang, DL
DOI：
10.1016/j.mrfmmm.2009.04.010
发表时间：
2009-10-02
影响因子：
2.3
作者：
Rossner, P., Jr.;Milcova, A.;Sram, R. J.
通讯作者：
Sram, R. J.
影响因子：
10.4
作者：
Herbstman JB;Tang D;Zhu D;Qu L;Sjödin A;Li Z;Camann D;Perera FP
通讯作者：
Perera FP