Protein Z and protein Z-dependent protease inhibitor
Protein Z and protein Z-dependent protease inhibitor
复制标题
Protein Z 和 Protein Z 依赖性蛋白酶抑制剂
作者：
A. Al;A. van Hylckama Vlieg;E. Berntorp;F. Rosendaal;G. Broze
为了评估蛋白Z(PZ)和蛋白Z依赖的蛋白酶抑制物(ZPI)在静脉血栓形成中的潜在作用，我们检测了426例静脉血栓形成患者和471名正常对照的血浆中PZ和ZPI的水平。在整个病例对照研究中，未发现PZ或ZPI水平与静脉血栓形成之间的关系。PZ和ZPI作为一个复合体循环，它们的血浆水平相互依赖。口服避孕药后PZ和ZPI均增加，口服抗凝治疗后PZ和ZPI均降低。
Summary To assess the potential roles of protein Z (PZ) and protein Z-dependent protease inhibitor (ZPI) in venous thrombosis, their plasma levels were measured in 426 individuals with venous thrombosis and 471 control individuals participating in the Leiden Thrombophilia Study. A relationship between the level of PZ or ZPI and venous thrombosis was not detected in the overall case-control study. PZ and ZPI circulate as a complex and their plasma levels are interdependent. Both PZ and ZPI are increased with oral contraceptive use and reduced with oral anticoagulant therapy.
DOI：
10.1073/pnas.95.16.9250
发表时间：
1998-08-04
影响因子：
11.1
作者：
Han, X;Fiehler, R;Broze, GJ
通讯作者：
Broze, GJ
影响因子：
20.3
作者：
J. Miletich;G. Broze
通讯作者：
J. Miletich;G. Broze
DOI：
10.1016/0006-291x(90)91566-b
发表时间：
1990-11-15
影响因子：
3.1
作者：
ICHINOSE, A;TAKEYA, H;DAVIE, EW
通讯作者：
DAVIE, EW