The age of the target cell affects B-cell leukaemia malignancy.
The age of the target cell affects B-cell leukaemia malignancy.
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DOI：
10.18632/aging.100244
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发表时间：
2010-12
期刊：
影响因子：
--
通讯作者：
Sánchez-García I
中科院分区：
文献类型：
--
作者：
Vicente-Dueñas C;Abollo-Jiménez F;Ruiz-Roca L;Alonso-Escudero E;Jiménez R;Cenador MB;Criado FJ;Cobaleda C;Sánchez-García I
The incidence, malignancy and treatment resistance of many types of human B-cell leukaemias (B-ALL) are directly related to patient age. A major obstacle to elucidate the contribution of age to the development and evolution of leukaemias is the lack of appropriate mouse models where precise control of the timing of oncogene expression is possible. Here we present proof-of-principle experiments showing how a conditional transgenic mouse model of BCR-ABLp190-driven B-ALL offers the opportunity to test the hypothesis that the age of the leukemic cells-of-origin of B-ALL influences B-ALL malignancy. B-ALLs generated from 12- and 20-month-old progenitors gave rise to a more invasive B-ALL than the one developed from 4-month old precursors. This was evidenced by survival analysis revealing the increased malignancy of B-ALLs generated from 20 or 12-month-old transformed progenitors compared with the 4-month equivalents (median survival of 88 days versus 50.5 and 33 days, respectively). Our study shows that the age of target cells at the time of transformation affects B-ALL malignancy.
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影响因子：
20.3
作者：
Cox, CV;Evely, RS;Blair, A
通讯作者：
Blair, A
影响因子：
8
作者：
Perez-Caro, M.;Gutierrez-Cianca, N.;Sanchez-Garcia, I.
通讯作者：
Sanchez-Garcia, I.
影响因子：
4.4
作者：
Miller, JP;Allman, D
通讯作者：
Allman, D
影响因子：
32.4
作者：
Schebesta, Alexandra;McManus, Shane;Busslinger, Meinrad
通讯作者：
Busslinger, Meinrad
DOI：
10.1073/pnas.1005486107
发表时间：
2010-12-14
影响因子：
11.1
作者：
Henry, Curtis J.;Marusyk, Andriy;DeGregori, James
通讯作者：
DeGregori, James