Clinical prevalence of Lewy body dementia.
Clinical prevalence of Lewy body dementia.
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DOI：
10.1186/s13195-018-0350-6
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发表时间：
2018-02-15
期刊：
影响因子：
--
通讯作者：
O'Brien JT
中科院分区：
文献类型：
--
作者：
Kane JPM;Surendranathan A;Bentley A;Barker SAH;Taylor JP;Thomas AJ;Allan LM;McNally RJ;James PW;McKeith IG;Burn DJ;O'Brien JT
在常规临床实践中，路易体痴呆（DLB）和帕金森病痴呆（PDD）的患病率尚不清楚。在临床和基于人群的队列和神经病理学研究中观察到的患病率差异很大。这些研究中的小样本量和方法学因素限制了临床实践的普遍性。我们调查了一个病例系列的患病率在9个二级保健服务超过18个月的时间，以确定如何常见的DLB和PDD病例的诊断和审查在英国的两个地区。DLB患者占所有痴呆病例的4.6%（95% CI 4.0-5.2%）。在东北部的服务机构中，DLB在痴呆病例中所占比例（5.6%）显著高于东安格利亚（3.3%; χ2 = 13.6，p < 0.01）。个别服务的DLB患病率为2.4%至5.9%。PDD占帕金森病病例的9.7%（95% CI 8.3-11.1%）。不同地区或不同服务部门之间的PDD患病率没有显着差异。我们发现，DLB的临床诊断频率在英国的地理区域之间存在差异，并且DLB和PDD的患病率远低于本病例系列中的预期，这表明这两种疾病的诊断率相当低。这两个地区DLB诊断率的显著差异可能反映了疾病患病率的真实差异，但更可能是诊断实践的差异。系统地引入更标准化的诊断实践可以提高这两种疾病的诊断率。
The prevalence of dementia with Lewy bodies (DLB) and dementia in Parkinson’s disease (PDD) in routine clinical practice is unclear. Prevalence rates observed in clinical and population-based cohorts and neuropathological studies vary greatly. Small sample sizes and methodological factors in these studies limit generalisability to clinical practice. We investigated prevalence in a case series across nine secondary care services over an 18-month period, to determine how commonly DLB and PDD cases are diagnosed and reviewed within two regions of the UK. Patients with DLB comprised 4.6% (95% CI 4.0–5.2%) of all dementia cases. DLB was represented in a significantly higher proportion of dementia cases in services in the North East (5.6%) than those in East Anglia (3.3%; χ2 = 13.6, p < 0.01). DLB prevalence in individual services ranged from 2.4 to 5.9%. PDD comprised 9.7% (95% CI 8.3–11.1%) of Parkinson’s disease cases. No significant variation in PDD prevalence was observed between regions or between services. We found that the frequency of clinical diagnosis of DLB varied between geographical regions in the UK, and that the prevalence of both DLB and PDD was much lower than would be expected in this case series, suggesting considerable under-diagnosis of both disorders. The significant variation in DLB diagnostic rates between these two regions may reflect true differences in disease prevalence, but more likely differences in diagnostic practice. The systematic introduction of more standardised diagnostic practice could improve the rates of diagnosis of both conditions.
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DOI：
10.1176/appi.neuropsych.13.3.374
发表时间：
2001-06-01
影响因子：
2.9
作者：
Aarsland, D;Ballard, C;Larsen, JP
通讯作者：
Larsen, JP
影响因子：
9.9
作者：
Fillenbaum, GG;Huber, MS;Harrell, LE
通讯作者：
Harrell, LE
影响因子：
3.7
作者：
Yoshita M;Arai H;Arai H;Arai T;Asada T;Fujishiro H;Hanyu H;Iizuka O;Iseki E;Kashihara K;Kosaka K;Maruno H;Mizukami K;Mizuno Y;Mori E;Nakajima K;Nakamura H;Nakano S;Nakashima K;Nishio Y;Orimo S;Samuraki M;Takahashi A;Taki J;Tokuda T;Urakami K;Utsumi K;Wada K;Washimi Y;Yamasaki J;Yamashina S;Yamada M
通讯作者：
Yamada M
影响因子：
9.9
作者：
Buter, T. C.;van den Hout, A.;Aarsland, D.
通讯作者：
Aarsland, D.
影响因子：
9.9
作者：
Williams, Monique M.;Xiong, Chengjie;Galvin, James E.
通讯作者：
Galvin, James E.