Convergence of Cancer Metabolism and Immunity: an Overview.
Convergence of Cancer Metabolism and Immunity: an Overview.
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DOI：
10.4062/biomolther.2017.194
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发表时间：
2018-01-01
影响因子：
3.7
通讯作者：
Kim JW
中科院分区：
文献类型：
--
作者：
Dang CV;Kim JW
Cancer metabolism as a field of research was founded almost 100 years ago by Otto Warburg, who described the propensity for cancers to convert glucose to lactate despite the presence of oxygen, which in yeast diminishes glycolytic metabolism known as the Pasteur effect. In the past 20 years, the resurgence of interest in cancer metabolism provided significant insights into processes involved in maintenance metabolism of non-proliferating cells and proliferative metabolism, which is regulated by proto-oncogenes and tumor suppressors in normal proliferating cells. In cancer cells, depending on the driving oncogenic event, metabolism is re-wired for nutrient import, redox homeostasis, protein quality control, and biosynthesis to support cell growth and division. In general, resting cells rely on oxidative metabolism, while proliferating cells rewire metabolism toward glycolysis, which favors many biosynthetic pathways for proliferation. Oncogenes such as MYC, BRAF, KRAS, and PI3K have been documented to rewire metabolism in favor of proliferation. These cell intrinsic mechanisms, however, are insufficient to drive tumorigenesis because immune surveillance continuously seeks to destroy neo-antigenic tumor cells. In this regard, evasion of cancer cells from immunity involves checkpoints that blunt cytotoxic T cells, which are also attenuated by the metabolic tumor microenvironment, which is rich in immuno-modulating metabolites such as lactate, 2-hydroxyglutarate, kynurenine, and the proton (low pH). As such, a full understanding of tumor metabolism requires an appreciation of the convergence of cancer cell intrinsic metabolism and that of the tumor microenvironment including stromal and immune cells.
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影响因子：
64.8
作者：
Sousa CM;Biancur DE;Wang X;Halbrook CJ;Sherman MH;Zhang L;Kremer D;Hwang RF;Witkiewicz AK;Ying H;Asara JM;Evans RM;Cantley LC;Lyssiotis CA;Kimmelman AC
通讯作者：
Kimmelman AC
影响因子：
29
作者：
Pavlova NN;Thompson CB
通讯作者：
Thompson CB
DOI：
10.1038/nrc.2016.84
发表时间：
2016-09-23
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
Nakazawa MS;Keith B;Simon MC
通讯作者：
Simon MC
影响因子：
4.1
作者：
ARDAWI, MSM;NEWSHOLME, EA
通讯作者：
NEWSHOLME, EA
影响因子：
5.7
作者：
Gross, Matt I.;Demo, Susan D.;Bennett, Mark K.
通讯作者：
Bennett, Mark K.