Syndecan-4-expressing muscle progenitor cells in the SP engraft as satellite cells during muscle regeneration.
Syndecan-4-expressing muscle progenitor cells in the SP engraft as satellite cells during muscle regeneration.
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DOI：
10.1016/j.stem.2009.01.016
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发表时间：
2009-03-06
期刊：
影响因子：
23.9
通讯作者：
Olwin BB
中科院分区：
文献类型：
--
作者：
Tanaka KK;Hall JK;Troy AA;Cornelison DD;Majka SM;Olwin BB
骨骼肌卫星细胞位于肌纤维的基膜和质膜之间，是骨骼肌再生所必需的。卫星细胞以及包括成中血管细胞、间充质干细胞和侧群（SP）细胞的其他细胞谱系有助于肌肉再生的能力使卫星干细胞的鉴定复杂化。我们已经表征了肌肉SP的一个罕见子集，其在移植到再生肌肉中时有效地移植到宿主卫星细胞龛中，分别提供75%的卫星细胞群体和30%的肌细胞群体。这些细胞位于卫星细胞位置，粘附在分离的肌纤维上，并在培养中自发地进行肌发生。我们建议，这一子集的SP细胞（卫星SP细胞）的ABCG 2，Syndecan-4和Pax 7的表达，构成了一个自我更新的肌肉干细胞能够产生卫星细胞和他们的myocardial后代在体内。
Skeletal muscle satellite cells, located between the basal lamina and plasma membrane of myofibers, are required for skeletal muscle regeneration. The capacity of satellite cells as well as other cell lineages including mesoangioblasts, mesenchymal stem cells and side population (SP) cells to contribute to muscle regeneration has complicated the identification of a satellite stem cell. We have characterized a rare subset of the muscle SP that efficiently engraft into the host satellite cell niche when transplanted into regenerating muscle, providing 75% of the satellite cell population and 30% of the myonuclear population, respectively. These cells are found in the satellite cell position, adhere to isolated myofibers, and spontaneously undergo myogenesis in culture. We propose that this subset of SP cells (satellite-SP cells) characterized by ABCG2, Syndecan-4 and Pax7 expression, constitutes a self-renewing muscle stem cell capable of generating both satellite cells and their myonuclear progeny in vivo.
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影响因子：
7.8
作者：
Asakura, Atsushi;Seale, Patrick;Girgis-Gabardo, Adele;Rudnicki, Michael A
通讯作者：
Rudnicki, Michael A
影响因子：
64.8
作者：
Sacco, Alessandra;Doyonnas, Regis;Kraft, Peggy;Vitorovic, Stefan;Blau, Helen M.
通讯作者：
Blau, Helen M.
影响因子：
2.7
作者：
Olguin, HC;Olwin, BB
通讯作者：
Olwin, BB
DOI：
10.1073/pnas.86.4.1292
发表时间：
1989-02-01
影响因子：
11.1
作者：
CHAPMAN, VM;MILLER, DR;CASKEY, CT
通讯作者：
CASKEY, CT
影响因子：
7.8
作者：
De Angelis, L;Berghella, L;Coletta, M;Lattanzi, L;Zanchi, M;Cusella-De Angelis, MG;Ponzetto, C;Cossu, G
通讯作者：
Cossu, G