Glucose metabolism in sporadic Creutzfeldt-Jakob disease: a statistical parametric mapping analysis of (18) F-FDG PET.
Glucose metabolism in sporadic Creutzfeldt-Jakob disease: a statistical parametric mapping analysis of (18) F-FDG PET.
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DOI：
10.1111/j.1468-1331.2011.03570.x
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发表时间：
2012-03
影响因子：
5.1
通讯作者：
Jeong Y
中科院分区：
文献类型：
--
作者：
Kim EJ;Cho SS;Jeong BH;Kim YS;Seo SW;Na DL;Geschwind MD;Jeong Y
在散发性克雅氏病（sCJD）中描述功能性神经成像技术，如正电子发射断层扫描（PET）和单光子发射计算机断层扫描（SPECT）的报告一致表明，这些工具对于识别低灌注或低代谢区域是敏感的，即使在sCJD的早期阶段也是如此。然而，关于[18F]氟-2-脱氧-d -葡萄糖（FDG） PETin在sCJD中的应用报道较少，且多为个案报道。迄今为止，仅发表了两项基于目视检查或感兴趣区域方法的小型队列研究。利用18F-FDG PET的统计参数映射（SPM）分析，我们研究了sCJD中是否存在优先受影响的脑区。在控制了年龄和性别后，我们使用spm2比较了i) 11名sCJD患者和35名对照者以及ii) 5名Heidenhain变体sCJD患者和35名对照者的葡萄糖代谢。sCJD患者表现为双侧顶叶、额叶和枕叶皮质糖代谢降低。Heidenhain型sCJD主要表现为双侧枕区葡萄糖代谢低下。在广泛的皮质区域检测到sCJD的葡萄糖低代谢；然而，在基底神经节或丘脑中没有发现，这两个部位经常被报道在弥散加权图像上受到影响。内侧颞区可能对朊病毒沉积具有抵抗力，sCJD也较少涉及。
Reports describing functional neuroimaging techniques, such as positron emission tomography (PET) and single photon emission computed tomography (SPECT), in sporadic Creutzfeldt-Jakob disease (sCJD) have consistently suggested that these tools are sensitive for the identification of areas of hypoperfusion or hypometabolism, even in the early stages of sCJD. However, there are few reports on the use of [18F]fluoro-2-deoxy-D-glucose (FDG) PETin sCJD and most of them are single case reports. Only two small cohort studies based on visual inspection or a region of interest method have been published to date. Using a statistical parametric mapping (SPM) analysis of 18F-FDG PET, we investigated whether there are brain regions preferentially affected in sCJD. After controlling for age and gender, using SPM 2 we compared the glucose metabolism between i) 11 patients with sCJD and 35 controls and ii) the subset of 5 patients with the Heidenhain variant of sCJD and 35 controls. The patients with sCJD showed decreased glucose metabolism in bilateral parietal, frontal, and occipital cortices. The Heidenhain variant of sCJD showed glucose hypometabolism mainly in bilateral occipital areas. Glucose hypometabolism in sCJD was detected in extensive cortical regions; however, it was not found in the basal ganglia or thalamus, which are frequently reported to be affected on diffusion-weighted images. The medial temporal area, which is possibly resistant to the prion deposits, was also less involved in sCJD.
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影响因子：
2.4
作者：
Bavis, J;Reynolds, P;Clark, P
通讯作者：
Clark, P
影响因子：
4.7
作者：
Cambier, DM;Kantarci, K;Aksamit, AJ
通讯作者：
Aksamit, AJ
影响因子：
9.9
作者：
Manners, D. N.;Parchi, P.;Barbiroli, B.
通讯作者：
Barbiroli, B.
影响因子：
2.1
作者：
Geschwind MD;Potter CA;Sattavat M;Garcia PA;Rosen HJ;Miller BL;DeArmond SJ
通讯作者：
DeArmond SJ
影响因子：
--
作者：
Na, DL;Suh, CK;Adair, JC
通讯作者：
Adair, JC