Overexpression of P4HA1 associates with poor prognosis and promotes cell proliferation and metastasis of lung adenocarcinoma.
Overexpression of P4HA1 associates with poor prognosis and promotes cell proliferation and metastasis of lung adenocarcinoma.
复制标题
P4HA1过表达与肺腺癌不良预后相关并促进细胞增殖和转移
DOI：
10.7150/jca.63147
复制
发表时间：
2021
影响因子：
3.9
通讯作者：
Fan S
中科院分区：
文献类型：
--
作者：
Ning Y;Zheng H;Zhan Y;Liu S;Yang Y;Zang H;Wen Q;Zhang Y;Fan S
Prolyl 4-hydroxylase subunit alpha 1 (P4HA1) is the core active catalytic portion of prolyl 4-hydroxylase, and has contributed to tumorigenesis in several cancers. In this study, we identified that P4HA1 mRNA and protein are both up-regulated in non-small cell lung cancer (NSCLC). Besides, overexpressed P4HA1 is correlated with poor clinical outcomes and serve as an independent prognosis biomarker in lung adenocarcinoma (LUAD), but not lung squamous cell carcinoma (LUSC). In vitro studies, decreased P4HA1 significantly inhibits proliferation and cell cycle, by regulating cyclin-dependent kinases (CDKs), cyclins and CDK inhibitor (CKI). Moreover, via inhibiting epithelial-mesenchymal transition (EMT) and matrix metalloprotease (MMPs), dysregulation of P4HA1 could restrain the tumor cell invasion and metastasis of lung adenocarcinoma. In addition, we found that P4HA1 could enhance cell stemness and cisplatin-resistance in lung adenocarcinoma. In summary, P4HA1 plays a crucial role in the development of NSCLC and may provide a brand-new target for lung cancer treatment.
登录
查看更多内容
影响因子：
7.3
作者：
Gao J;Aksoy BA;Dogrusoz U;Dresdner G;Gross B;Sumer SO;Sun Y;Jacobsen A;Sinha R;Larsson E;Cerami E;Sander C;Schultz N
通讯作者：
Schultz N
影响因子：
16.6
作者：
Xiong G;He P;Lyu Z;Chen T;Huang B;Chen L;Fisher TS
通讯作者：
Fisher TS
影响因子：
11.2
作者：
Gilkes DM;Chaturvedi P;Bajpai S;Wong CC;Wei H;Pitcairn S;Hubbi ME;Wirtz D;Semenza GL
通讯作者：
Semenza GL
DOI：
10.1016/j.bbrc.2019.06.096
发表时间：
2019-08-27
影响因子：
3.1
作者：
Cao, X. P.;Cao, Y.;Zhu, Z. M.
通讯作者：
Zhu, Z. M.
影响因子：
3.9
作者：
Duan, Yanan;Dong, Yinghui;Cheng, Jianxin
通讯作者：
Cheng, Jianxin