Primary care incidence and treatment of four neuropathic pain conditions: a descriptive study, 2002-2005.
Primary care incidence and treatment of four neuropathic pain conditions: a descriptive study, 2002-2005.
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DOI：
10.1186/1471-2296-9-26
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发表时间：
2008-05-06
影响因子：
2.9
通讯作者：
McQuay HJ
中科院分区：
文献类型：
--
作者：
Hall GC;Carroll D;McQuay HJ
在1992至2001年间，英国全科医生带状疱疹后神经痛和三叉神经痛的发生率下降，而痛性糖尿病神经病变的发生率上升。最常见的一线治疗是复合止痛药。由于治疗方案随后发生了变化，这项研究提供了神经病理性疼痛的发生率和处方模式的最新数据。使用2002年5月至2005年7月的英国计算机全科医疗记录对确诊为带状疱疹后神经痛(n=1,923)、三叉神经痛(1,862)、幻肢痛(57)和痛性糖尿病神经病变(1,444)的流行病学和处方治疗进行描述性分析。每10万人年初级保健事件报告带状疱疹后神经痛28例(95%可信区间27-30)，三叉神经痛27例(95%可信区间26-29)，幻肢痛0.8例(95%可信区间0.6-1.1)，痛性糖尿病神经病变21例(95%可信区间20-22)。最常见的初始治疗是三环类抗抑郁药(带状疱疹后神经痛)或抗癫痫药(三叉神经痛和痛性糖尿病神经病变)和阿片类止痛药(幻肢痛)。在稳定的药物方案之前，三叉神经痛、疼痛性糖尿病神经病变和带状疱疹后神经痛的平均变化次数为1.2至1.5，幻肢疼痛的平均变化次数为2.4。幻肢痛和带状疱疹后神经痛的发生率正在下降，而疼痛的糖尿病神经病变停滞不前，三叉神经痛保持不变。尽管与传统的非阿片类止痛药相比，一线治疗更频繁地使用抗抑郁药和抗癫痫药，但在达到稳定的治疗方案之前，改变治疗方法是很常见的。
Between 1992 and 2001 the UK general practice incidence of post-herpetic neuralgia and trigeminal neuralgia declined, whilst the incidence of painful diabetic neuropathy increased. The most common first line treatments were compound analgesics. As therapeutic options have subsequently changed, this study presents updated data on incidence and prescribing patterns in neuropathic pain. A descriptive analysis of the epidemiology and prescription treatment at diagnosis of incident post-herpetic neuralgia (n = 1,923); trigeminal neuralgia (1,862); phantom limb pain (57) and painful diabetic neuropathy (1,444) using computerised UK general practice records (THIN): May 2002 to July 2005. Primary care incidences per 100,000 person years observation of 28 (95% confidence interval (CI) 27–30) for post-herpetic neuralgia, 27 (95%CI 26–29) for trigeminal neuralgia, 0.8 (95%CI 0.6–1.1) for phantom limb pain and 21 (95%CI 20–22) for painful diabetic neuropathy are reported. The most common initial treatments were tricyclic antidepressants (post-herpetic neuralgia) or antiepileptics (trigeminal neuralgia and painful diabetic neuropathy) and opioid analgesics (phantom limb pain). The mean number of changes before a stable drug regimen was 1.2 to 1.5 for trigeminal neuralgia, painful diabetic neuropathy and post-herpetic neuralgia, and 2.4 for phantom limb pain. The incidence of phantom limb pain and post-herpetic neuralgia are decreasing whilst painful diabetic neuropathy plateaued and trigeminal neuralgia remained constant. Despite more frequent use of antidepressants and antiepileptics for first line treatment, as opposed to conventional non-opioid analgesics, changes to therapy are common before a stable regimen is reached.
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影响因子：
7.4
作者：
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通讯作者：
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影响因子：
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影响因子：
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