Dendritic spine changes associated with normal aging.
Dendritic spine changes associated with normal aging.
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DOI：
10.1016/j.neuroscience.2012.09.077
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发表时间：
2013-10-22
期刊：
影响因子：
3.3
通讯作者：
Hof, P. R.
中科院分区：
文献类型：
--
作者：
Dickstein, D. L.;Weaver, C. M.;Luebke, J. I.;Hof, P. R.
鉴于人口老龄化速度快，老年人认知能力下降和神经退行性疾病的发病率增加，确定导致认知障碍的决定因素十分重要。同样重要的是要注意，许多老年人口表现出“成功的”认知老化，其中认知障碍是最小的。正常老化研究的一个主要目标是区分发生在不成功（功能受损）受试者与成功（功能未受损）受试者中的神经变化。在这篇综述中，我们提出了一些神经元和脊柱在整个正常衰老过程中经历的结构适应，并讨论了它们对电生理特性和认知的可能贡献。衰老过程中神经元和树突棘的结构变化，以及这种变化的功能后果，仍然知之甚少。阐明导致认知障碍的结构和功能性突触年龄相关变化可能会导致开发可以恢复或保护神经回路并介导认知和成功衰老的药物治疗。
Given the rapid rate of population aging and the increased incidence of cognitive decline and neurodegenerative diseases with advanced age, it is important to ascertain the determinants that result in cognitive impairment. It is also important to note that some many of the aged population exhibit ‘successful’ cognitive aging, in which cognitive impairment is minimal. One main goal of normal aging studies is to distinguish the neural changes that occur in unsuccessful (functionally impaired) subjects from those of successful (functionally unimpaired) subjects. In this review, we present some of the structural adaptations that neurons and spines undergo throughout normal aging and discuss their likely contributions to electrophysiological properties and cognition. Structural changes of neurons and dendritic spines during aging, and the functional consequences of such changes, remain poorly understood. Elucidating the structural and functional synaptic age-related changes that lead to cognitive impairment may lead to the development of drug treatments that can restore or protect neural circuits and mediate cognition and successful aging.
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DOI：
10.1523/jneurosci.0759-10.2010
发表时间：
2010-05-12
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bloss EB;Janssen WG;McEwen BS;Morrison JH
通讯作者：
Morrison JH
DOI：
10.1523/jneurosci.2581-12.2012
发表时间：
2012-10-03
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Amatrudo JM;Weaver CM;Crimins JL;Hof PR;Rosene DL;Luebke JI
通讯作者：
Luebke JI
影响因子：
11.2
作者：
Adams, M;Dulchinos, D
通讯作者：
Dulchinos, D
影响因子：
4.2
作者：
ALBERT, M
通讯作者：
ALBERT, M
影响因子：
4.2
作者：
Brennan, Avis R.;Yuan, Peixiong;Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.