Exercise-induced pain and analgesia? Underlying mechanisms and clinical translation.

Exercise-induced pain and analgesia? Underlying mechanisms and clinical translation.
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DOI:
10.1097/j.pain.0000000000001235
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发表时间:
2018-09
期刊:
影响因子:
7.4
通讯作者:
Hoeger Bement M
Hoeger Bement M
中科院分区:
医学1区
文献类型:
--
作者:
Sluka KA;Frey-Law L;Hoeger Bement M

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剧烈的体育活动和锻炼会增加慢性疼痛患者的疼痛,但定期锻炼是一种有效的治疗方法。这篇综述将通过总结人类和动物的研究来讨论这两种截然不同的发现。我们将提供支持体育活动在调节中枢神经系统兴奋性和抑制、免疫系统功能和与疼痛相关的心理结构中的作用的数据。我们展示的证据表明,久坐状态与中枢神经系统(脑干抑制/促进部位)和免疫系统的更大兴奋性和更少抑制有关。我们进一步表明,锻炼和有规律的体育活动可以降低兴奋性,改善中枢神经系统(脑干抑制/促进部位)和免疫系统的抑制作用。然后我们将讨论这些发现的临床意义,对运动的临床应用提出建议,并提出未来的研究方向。
An acute bout of physical activity and exercise can increase pain in individuals with chronic pain, but regular exercise is an effective treatment. This review will discuss these two dichotomous findings by summarizing studies in human and animal subjects. We will provide the data that supports the role of physical activity in modulating central nervous system excitability and inhibition, immune system function, and psychological constructs associated with pain. We show evidence that the sedentary condition is associated with greater excitability and less inhibition in both the central nervous system (brainstem inhibitory/facilitatory sites) and the immune system. We further show that exercise and regular physical activity decreases excitability and improves inhibition in both the central nervous system (brainstem inhibitory/facilitatory sites) and the immune system. We will then discuss the clinical implications of these findings, make recommendations for clinical application of exercise, and suggest future research directions.
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