Molecular Pathways Modulating Sensory Hair Cell Regeneration in Adult Mammalian Cochleae: Progress and Perspectives.
Molecular Pathways Modulating Sensory Hair Cell Regeneration in Adult Mammalian Cochleae: Progress and Perspectives.
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DOI：
10.3390/ijms23010066
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发表时间：
2021-12-22
影响因子：
5.6
通讯作者：
Zuo J
中科院分区：
文献类型：
--
作者：
Rai V;Tu S;Frank JR;Zuo J
噪声引起的、药物相关的和年龄相关的致残性听力损失是一个主要的公共卫生问题，影响着全球约4.66亿人。在非哺乳类脊椎动物中，感觉毛细胞（HC）的死亡诱导邻近的支持细胞增殖和转分化为新的HC;然而，这种能力在幼年和成年哺乳动物耳蜗中丧失，导致永久性听力损失。目前，人工耳蜗和助听器是唯一可用的治疗方法，可以在一定程度上帮助患者;然而，没有生物学方法或FDA批准的药物可以有效治疗致残性听力损失并恢复听力。最近，通过调节分子通路或转录因子再生哺乳动物耳蜗毛细胞提供了一些有前途的结果，虽然再生毛细胞的不成熟仍然是最大的关注。此外，大多数研究都是在新生儿中进行的，而不是在成人中进行的。这篇综述着重于批判性地总结在成年哺乳动物耳蜗中所做的研究，并讨论了各种策略，以阐明新的转录因子，更好的治疗。
Noise-induced, drug-related, and age-related disabling hearing loss is a major public health problem and affect approximately 466 million people worldwide. In non-mammalian vertebrates, the death of sensory hair cells (HCs) induces the proliferation and transdifferentiation of adjacent supporting cells into new HCs; however, this capacity is lost in juvenile and adult mammalian cochleae leading to permanent hearing loss. At present, cochlear implants and hearing devices are the only available treatments and can help patients to a certain extent; however, no biological approach or FDA-approved drug is effective to treat disabling hearing loss and restore hearing. Recently, regeneration of mammalian cochlear HCs by modulating molecular pathways or transcription factors has offered some promising results, although the immaturity of the regenerated HCs remains the biggest concern. Furthermore, most of the research done is in neonates and not in adults. This review focuses on critically summarizing the studies done in adult mammalian cochleae and discusses various strategies to elucidate novel transcription factors for better therapeutics.
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影响因子：
7.3
作者：
Doetzlhofer A;Avraham KB
通讯作者：
Avraham KB
影响因子：
2.5
作者：
Hayashi, Toshinori;Ray, Catherine A.;Younkins, Christa;Bermingham-McDonogh, Olivia
通讯作者：
Bermingham-McDonogh, Olivia
影响因子：
5.7
作者：
Edge AS;Chen ZY
通讯作者：
Chen ZY
影响因子：
2.5
作者：
Cafaro, Jon;Lee, Gi Soo;Stone, Jennifer S.
通讯作者：
Stone, Jennifer S.
DOI：
10.1523/jneurosci.0312-08.2008
发表时间：
2008-07-16
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Driver EC;Pryor SP;Hill P;Turner J;Rüther U;Biesecker LG;Griffith AJ;Kelley MW
通讯作者：
Kelley MW