Innate immunity and the role of defensins in otitis media.
Innate immunity and the role of defensins in otitis media.
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DOI：
10.1007/s11882-011-0223-6
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发表时间：
2011-12
影响因子：
5.5
通讯作者：
Bakaletz, Lauren
中科院分区：
文献类型：
--
作者：
Underwood, Mark;Bakaletz, Lauren
中耳炎是发达国家最常见的儿科疾病，也是发展中国家发病率和听力损失的重要原因。先天免疫系统对于保护中耳免受感染至关重要。防御素是一种广谱阳离子抗菌肽，与急性中耳炎的预防和早期反应有关;然而，防御素和其他抗菌分子介导这种保护的机制尚未完全阐明。在动物中耳炎模型和人中耳上皮细胞培养模型中，β-防御素均被高度诱导并有效地杀死与中耳炎相关的常见病原体。我们回顾了先天免疫在保护中耳中的重要性，以及防御素和其他抗菌分子在预防和治疗中耳炎中的作用的最新进展。尽管存在复杂的先天性和适应性免疫系统，但中耳炎的极高患病率仍是临床医生和科学家的一个令人烦恼的问题。因此，我们还审查了细菌逃避先天免疫防御的机制。
Otitis media is the most common pediatric disease in developed countries and a significant cause of morbidity and hearing loss in developing countries. The innate immune system is essential to protecting the middle ear from infection. Defensins, broad-spectrum cationic antimicrobial peptides, have been implicated in prevention of and the early response to acute otitis media; however, the mechanisms by which defensins and other antimicrobial molecules mediate this protection have not been completely elucidated. In both animal otitis media models and human middle ear epithelial cell culture models, β-defensins are highly induced and effectively kill the common pathogens associated with otitis media. We review the importance of innate immunity in protecting the middle ear and recent advances in understanding the roles of defensins and other antimicrobial molecules in the prevention and treatment of otitis media. The extremely high prevalence of otitis media, in spite of sophisticated innate and adaptive immune systems, is a vexing problem for clinicians and scientists. We therefore also review mechanisms by which bacteria evade innate immune defenses.
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影响因子：
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