Genetic dissection reveals two separate retinal substrates for polarization vision in Drosophila.
Genetic dissection reveals two separate retinal substrates for polarization vision in Drosophila.
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DOI：
10.1016/j.cub.2011.11.028
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发表时间：
2012-01-10
期刊：
影响因子：
9.2
通讯作者：
Clandinin, Thomas R.
中科院分区：
文献类型：
--
作者：
Wernet, Mathias F.;Velez, Mariel M.;Clark, Damon A.;Baumann-Klausener, Franziska;Brown, Julian R.;Klovstad, Martha;Labhart, Thomas;Clandinin, Thomas R.
线偏振光源自大气散射或表面反射，被昆虫、蜘蛛、头足类甲壳类动物和一些脊椎动物感知。因此，如何检测光的这种基本质量的神经基础引起了广泛的兴趣。形态独特、对偏振敏感的小眼存在于许多昆虫视网膜的背侧周边，形成“背缘区域”（DRA）。然而，人们对偏振反射行为反应的视网膜基质知之甚少。当刺激出现在背侧或腹侧时，果蝇表现出极化行为，自发地与线偏振光的 e 向量对齐。通过将行为实验与遗传解剖和超微结构分析相结合，我们发现不同的光感受器介导两种行为：DRA小眼的内部光感受器R7+R8对于背侧偏向性是必要且充分的，而腹侧反应是由外部和内部光感受器的组合介导的，这两者都表现出先前未知的特征，使它们对偏振敏感。果蝇使用单独的视网膜通路来检测从天空或闪亮表面发出的线偏振光。这项工作建立了一种行为范式，可以对偏振视觉背后的回路进行基因解剖。
Linearly polarized light originates from atmospheric scattering, or surface reflections, and is perceived by, insects, spiders, cephalopods crustaceans and some vertebrates. Thus, the neural basis underlying how this fundamental quality of light is detected is of broad interest. Morphologically unique, polarization-sensitive ommatidia exist in the dorsal periphery of many insect retinas, forming the ‘Dorsal Rim Area’ (DRA). However, much less is known about the retinal substrates of behavioral responses to polarized reflections. Drosophila exhibits polarotactic behavior, spontaneously aligning with the e-vector of linearly polarized light, when stimuli are presented either dorsally or ventrally. By combining behavioral experiments with genetic dissection and ultrastructural analyses, we show that distinct photoreceptors mediate the two behaviors: inner photoreceptors R7+R8 of DRA ommatidia are necessary and sufficient for dorsal polarotaxis, whereas ventral responses are mediated by combinations of outer and inner photoreceptors, both of which manifest previously unknown features that render them polarization-sensitive. Drosophila uses separate retinal pathways for the detection of linearly polarized light emanating from the sky, or from shiny surfaces. This work establishes a behavioral paradigm that will enable genetic dissection of the circuits underlying polarization vision.
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对横纹肌感光器的膜中色素旋转和翻译扩散的限制。
影响因子：
3.8
作者：
Goldsmith, T H;Wehner, R
通讯作者：
Wehner, R
DOI：
10.1007/bf00605006
发表时间：
1987-01-01
期刊：
JOURNAL OF COMPARATIVE PHYSIOLOGY A-SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
影响因子：
--
作者：
NILSSON, DE;LABHART, T;MEYER, E
通讯作者：
MEYER, E
DOI：
10.1016/0020-7322(81)90004-0
发表时间：
1981-01-01
期刊：
INTERNATIONAL JOURNAL OF INSECT MORPHOLOGY & EMBRYOLOGY
影响因子：
--
作者：
SMOLA, U;WUNDERER, H
通讯作者：
WUNDERER, H
DOI：
10.1007/s00359-005-0073-6
发表时间：
2006-03-01
影响因子：
2.1
作者：
Stalleicken, J;Labhart, T;Mouritsen, H
通讯作者：
Mouritsen, H
影响因子：
3.6
作者：
FORTINI, ME;RUBIN, GM
通讯作者：
RUBIN, GM